Capillaroscopic Insights: Exploring the Connection Between Microvascular Changes and Pulmonary Manifestations in Systemic Sclerosis.

Background: Systemic sclerosis (SSc) is a complex connective tissue disease characterized by microangiopathy, immune dysregulation, and fibrosis. Early detection of microvascular abnormalities using nailfold videocapillaroscopy (NVC) is crucial in assessing disease progression and associated disease's involvement such as interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH).

Objective: This study aims to explore the relationships correlation between NVC patterns, clinical manifestations, and systemic complications in SSc.

Subclinical Enthesopathy in Psoriasis-An Ultrasonographic Study.

The present study is aimed at assessing the presence and prevalence of subclinical entheseal changes in Psoriasis (PsO) patients using musculoskeletal ultrasonography (US), conjoined with the analysis of possible differences in terms of demographic, clinical, or biological features. We carried out an observational study on 54 patients with PsO and 40 controls. Subclinical enthesopathy, according to OMERACT definitions, was identified in 20 of the psoriasis patients (37.

Ultrasound Features in Gout: An Overview.

The accurate diagnosis of gout frequently constitutes a challenge in clinical practice, as it bears a close resemblance to other rheumatologic conditions. An undelayed diagnosis and an early therapeutic intervention using uric acid lowering therapy (ULT) is of the utmost importance for preventing bone destruction, the main point of managing gout patients. Advanced and less invasive imaging techniques are employed to diagnose the pathology and ultrasonography (US) stands out as a non-invasive, widely accessible and easily reproducible method with high patient acceptability, enabling the evaluation of the full clinical spectrum in gout.

Skin Ultrasound Assessment of Patients with Systemic Scleroderma-An Observational Study.

This study aims to analyze the changes in dermal thickness in patients with systemic scleroderma (SSc) in comparison with normal skin and also compare clinical forms with diffuse and limited cutaneous involvement. The study group consisted of female patients diagnosed with SSc with a disease history not exceeding 5 years. The areas of interest for ultrasound examination included the proximal phalanx of the third finger, the second intermetacarpal space, and the extension surface of the lower third of the forearm.

Hepatic vascular hamartoma in a cat: a case report with literature review.

Vascular hamartomas represent a focal proliferation of disorganized vascular tissue, which is usually present at birth. An 8-month-old Scottish fold female cat presented with abdominal distention, mild dyspnea, pale mucous membranes, and lethargy. Ultrasound examination revealed a hepatic mass resembling multiple cysts affecting the right medial lobe.

Review: A Contemporary, Multifaced Insight into Psoriasis Pathogenesis.

Psoriasis is a chronic recurrent inflammatory autoimmune pathology with a significant genetic component and several interferences of immunological cells and their cytokines. The complex orchestration of psoriasis pathogenesis is related to the synergic effect of immune cells, polygenic alterations, autoantigens, and several other external factors. The major act of the IL-23/IL-17 axis, strongly influencing the inflammatory pattern established during the disease activity, is visible as a continuous perpetuation of the pro-inflammatory response and keratinocyte activation and proliferation, leading to the development of psoriatic lesions.

Advances in Water, Air and Soil Pollution Monitoring, Modeling and Restoration.

Global pollution demands continuous attention and concerted efforts to reduce its effects [...

Assessing Benzene and TVOC Pollution and the Carcinogenic and Noncarcinogenic Risks to Workers in an Industrial Plant in Southeastern Romania.

The article aims to analyze the pollution with Volatile Organic Compounds (VOC) emitted from the biggest refinery in Romania, using the daily and monthly series registered for two years in two sites on the industrial platform, and the carcinogenic and noncarcinogenic risks for workers at the industrial plant. Since the values of the basic statistics (minimum, maximum, and average) and outliers indicate that most recorded values exceed the maximum admissible limits established by law, the Peaks Over Threshold (POT) method was utilized to model the maximum values of the series and determine the return levels for benzene and total VOC (TVOC). Given the high values obtained for relatively short return periods, indicating potential danger for the workers, we assessed the noncarcinogenic and carcinogenic risks to benzene and TVOC exposure by computing the hazard index (HI) and lifetime cancer risk (LCR).

Downscaling MERRA-2 Reanalysis PM Series over the Arabian Gulf by Inverse Distance Weighting, Bicubic Spline Smoothing, and Spatio-Temporal Kriging.

This study offers a detailed analysis of the fine particulate matter (PM) series in the Arabian Gulf zone, employing three interpolation models, Inverse Distance Weighting (IDW), Bicubic Spline Smoothing (BSS) and Spatio-Temporal Kriging (STK). Unique advancements include the use of complete temporal records in IDW, the management of edge effects in S with synthetic buffer points, and the application of STK to detrended data residuals. The results indicated that the BBS, particularly adept at handling boundary conditions, significantly outperformed the other methods.

Assessing the Efficiency of a Drinking Water Treatment Plant Using Statistical Methods and Quality Indices.

This study presents the efficiency of a drinking water treatment plant from Constanța, Romania. Individual and aggregated indices are proposed and built using nine water parameters for this aim. The analysis of individual indices permits the detection of the period of malfunctioning of the water treatment plant with respect to various parameters at various sampling points.

Microbiota-Accessible Boron-Containing Compounds in Complex Regional Pain Syndrome.

The microbiota-gut-brain axis has garnered increasing attention in recent years for its role in various health conditions, including neuroinflammatory disorders like complex regional pain syndrome (CRPS). CRPS is a debilitating condition characterized by chronic neuropathic pain, and its etiology and pathophysiology remain elusive. Emerging research suggests that alterations in the gut microbiota composition and function could play a significant role in CRPS development and progression.

Evaluating the Contamination by Indoor Dust in Dubai.

Nowadays, people spend most of their time indoors. Despite constantly cleaning these spaces, dust apparition cannot be avoided. Since dust can contain chemical elements that negatively impact people's health, we propose the analysis of the metals from the indoor dust component collected in different locations in Dubai, UAE.

Modeling the Greenhouse Gases Data Series in Europe during 1990-2021.

Nowadays, climate change and atmospheric pollution are two of humanity's most significant challenges. Greenhouse gases (GHGs) are responsible for climate change, and they create effects that are mostly irreversible. Therefore, monitoring and reducing such emissions are compulsory for the preservation of the environment for future generations.

Modeling the Chlorine Series from the Treatment Plant of Drinking Water in Constanta, Romania.

Ensuring good drinking water quality, which does not damage the population's health, should be a priority of decision factors. Therefore, water treatment must be carried out to remove the contaminants. Chlorination is one of the most used treatment procedures.

Human Health Risk Assessment to the Consumption of Medicinal Plants with Melliferous Potential from the Romanian South-Eastern Region.

This study presents the impact on human health by consuming medicinal herbs with high melliferous potential (HMPs) from botanical areas with different pollution levels. First, the bioaccumulation of the plants' parts has been determined. The study assessed the potential health risks associated with the ingestion of various mineral species (macroelements-K, Ca, Mg, Na; microelements-Fe, Mn, Cu, Zn, and one trace element Cd) from three types of HMPs ( (), (), and ()).

Fractal Characterization of the Mass Loss of Bronze by Erosion-Corrosion in Seawater.

The fractal approach is one of the nondestructive techniques for analyzing corrosion's effects on different materials. This article utilizes it to analyze the erosion-corrosion produced by cavitation on two types of bronze introduced into an ultrasonic cavitation field to investigate the differences between their behavior in saline water. The aim is to check the hypothesis that the fractal/multifractal measures significantly differ for the studied materials that belong to the same class (bronze) as a step in applying fractal techniques to distinguish between two materials.

MMP-13, VEGF, and Disease Activity in a Cohort of Rheumatoid Arthritis Patients.

Identifying certain serum biomarkers associated with the degree of rheumatoid arthritis (RA) activity can provide us with a more accurate view of the evolution, prognosis, and future quality of life for these patients. Our aim was to analyze the presence and clinical use of matrix metalloproteinase-13 (MMP-13), along with vascular endothelial growth factor (VEGF) and well-known cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) for patients with RA. We also wanted to identify the possible correlations between MMP-13 and these serological markers, as well as their relationship with disease activity indices, quality of life, and ultrasonographic evaluation.

Glucocorticoid exposure and the risk of serious infections in rheumatoid arthritis: a marginal structural model application.

Objective: Observational studies have reported an increased risk of infections associated with glucocorticoids in RA, not supported by evidence from randomized controlled trials. Inappropriately accommodating time-varying exposure and confounding in observational studies might explain the conflicting results. Therefore, we compared the incidence of serious infections between different oral glucocorticoid dose patterns over three years in a prospective inception cohort, adjusting for time-varying confounders in marginal structural models.