Publications by authors named "Barbro Larson"
Article Synopsis
- Vulvar squamous cell carcinoma (VSCC) is the fourth most common gynecological cancer, with two subtypes: one linked to high-risk human papilloma virus (HPV) and one that is HPV negative.
- The study investigated the relationship between HPV infection and the risk of relapse in VSCC by analyzing protein profiles from 14 tumor samples using advanced techniques like liquid-chromatography tandem mass spectrometry.
- The research identified four key proteins that could classify the relapse status and discovered alterations in the ubiquitin-proteasome pathway in tumors associated with high relapse risk, particularly in HPV-negative cases.
Evaluation of preoperative lymphoscintigraphy and sentinel node procedure in vulvar cancer.
Eur J Obstet Gynecol Reprod Biol
September 2010
Objective: To assess the value of preoperative lymphoscintigraphy, and to evaluate the validity and feasibility of the sentinel node (SN) procedure in vulvar carcinoma.
Study Design: Retrospective clinical and histopathological review of 77 patients with invasive squamous cell carcinoma in vulva who were treated at Karolinska University Hospital Stockholm, Sweden, from 2000 to 2007. The patients underwent SN mapping preoperatively with radioactive tracer and blue dye (n=60) or only blue dye (n=17).
Objective: To investigate the presence of HPV in VSCC and sentinel nodes (SN) in patients in Sweden and the possible influence of HPV on prognosis.
Patients And Materials: Primary tumors from 75 VSCC patients undergoing the SN procedure and SNs from 69 patients were tested for HPV DNA. Analyses were performed by PCR using general (GP5+/6+ and CPI/IIG) type-specific primers, and sequencing in paraffin-embedded VSCC and SN.
Erythropoietin and intravenous iron therapy in postpartum anaemia.
Acta Obstet Gynecol Scand
October 2007
Background: We assessed whether recombinant human erythropoietin (rhEPO) enhances a rise in haemoglobin concentration in postpartum anaemia compared to intravenous iron alone.
Design: Some 60 patients with haemoglobin values
Background: Effective screening programs have contributed to a decrease in the incidence of cervical squamous cell carcinomas but have had a limited sensitivity in the detection of adenocarcinoma precursor lesions. The aim of our study was to analyze cervical adenocarcinoma in greater detail: symptoms preceding the detection, the method of detection and the prevalence of human papillomavirus (HPV) with respect to age at diagnosis.
Material And Methods: Clinical data were abstracted from the medical records of 82 women with pure invasive cervical adenocarcinomas.
In a collection of 173 cervical adenocarcinomas, the prevalence of HPV in relation to the age of women and the distribution of the various oncogenic types of HPV were evaluated. The tumour material was analysed by PCR of the HPV L1 gene followed by direct DNA sequencing and/or the polymerase chain reaction and single-strand conformation polymorphism (PCR-SSCP) technique for the identification and typing of HPV. In 68% (117/173) of the adenocarcinomas, HPV was present.
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