Successful complete vaginectomy in dorsal recumbency: description of surgical technique without repositioning combining celiotomy and episiotomy in three dogs.

Objective: To describe a simultaneous surgical approach to the abdominal cavity and perineum for complete vaginectomy performed in dorsal recumbency and to create a schematic for guiding the procedure without the need for patient repositioning.

Animals: 3 client-owned dogs with urogenital pathology.

Clinical Presentation: The first dog, an 11-year-old neutered female Border Collie, presented with stranguria and tenesmus.

Acute upper airway obstruction as a life-threatening complication of ventral bulla osteotomy: report of two consecutive cases.

Case Summary: This paper presents two cases of acute postoperative upper airway obstruction following ventral bulla osteotomy (VBO) in cats. The first cat underwent a unilateral left-sided VBO for a suspected inflammatory polyp. The second cat underwent a single-session bilateral VBO procedure for bilateral otitis media.

Photochemical Oxidation of Pt(IV)Me(1,2-diimine) Thiolates to Luminescent Pt(IV) Sulfinates.

We report the formation of dinuclear complexes from, and photochemical oxidation of, (CH)-Pt(IV)(N^N) (N^N = 1,2-diimine derivatives) complexes of thiophenolate ligands to the analogous sulfinates (CH)Pt(N^N)(SOPh) and structural, spectroscopic, and theoretical studies of the latter revealing tunable photophysics depending upon the 1,2-diimine ligands. Electron-rich thiolate and conjugated 1,2-diimines encourage formation of thiolate-bridged dinuclear complexes; smaller 1,2-diimines or electron-poor thiolates favor mononuclear complexes. Photooxidation of the thiolate ligand yields hitherto unreported Pt(IV)-SOR complexes, promoted by electron-deficient thiolates such as 4-nitrothiophenol, which exclusively forms the sulfinate complex.

Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation .

Potential drug treatments for Alzheimer's disease (AD) may be found by identifying compounds that block the assembly of the microtubule-associated protein tau into neurofibrillar tangles associated with neuron destabilization and cell death. Here, a small library of structurally diverse compounds was screened for the ability to inhibit tau aggregation, using high-throughput synchrotron radiation circular dichroism as a novel tool to monitor the structural changes in the protein as it assembles into filaments. The catecholamine epinephrine was found to be the most effective tau aggregation inhibitor of all 88 screened compounds.