State of knowledge: Histolocalisation in phytochemical study of medicinal plants.

Background And Aim: The renewed interest in medicinal plants has led us to examine more closely the usefulness of metabolite histolocalisation in screening work before any in-depth phytochemical studies. Indeed, this method is a histochemical technique allowing characterizing plant tissues constituents; and in particular metabolites of therapeutic interest, without destroying or altering as much as possible the studied plant material. This work aims at allowing us carring out a wide screening to highlight bioactive metabolites in plants studied from our rich university heritage collection.

Copper(II) interactions with non-steroidal anti-inflammatory agents. III--3-Methoxyanthranilic acid as a potential *OH-inactivating ligand: a quantitative investigation of its copper handling role in vivo.

Pharmacological activities of copper(II) complexes are a direct function of the nature of their ligands associated with the metal ion in vivo. Some of these, defined as *OH-inactivating ligands (G. Berthon, Agents Actions 39 (1993) 210-217), may act as specific "lures" for hydroxyl radicals at inflammatory sites and behave as pseudo-catalase-like agents.