induces autoimmune peripheral neuropathy via Sialoadhesin and Interleukin-4 axes.

is a leading cause of gastroenteritis that has been causally linked with development of the autoimmune peripheral neuropathy Guillain Barré Syndrome (GBS). Previously, we showed that isolates from human enteritis patients induced Type1/17-cytokine dependent colitis in interleukin-10 (IL-10) mice, while isolates from GBS patients colonized these mice without colitis but instead induced autoantibodies that cross-reacted with the sialylated oligosaccharide motifs on the LOS of GBS-associated and the peripheral nerve gangliosides. We show here that infection of IL-10 mice with the GBS but not the colitis isolate led to sciatic nerve inflammation and abnormal gait and hind limb movements, with character and timing consistent with this syndrome in humans.

Fatal Canid herpesvirus 1 infection in an adult dog.

Canid herpesvirus 1 (CaHV-1) is a well-known cause of fatal hepatic and renal necrosis in neonatal puppies. In adult dogs infected with CaHV-1, papulovesicular genital lesions may be observed. CaHV-1 infection during pregnancy can lead to embryonic resorption, abortion, and stillbirth.

Pancreatic atrophy due to zinc toxicosis in two African ostriches (Struthio camelus).

Two of three captive adult African ostriches exhibited inappetance and weakness. In spite of treatment, the two birds were euthanized because of lack of clinical improvement. Postmortem examination demonstrated exocrine pancreatic degeneration, necrosis, and atrophy.