Extraction of Bioactive Compounds from Wine Lees: A Systematic and Bibliometric Review.

The extraction of bioactive compounds from wine lees involves a variety of methods, the selection of which is crucial to ensure optimal yields. This systematic review, following PRISMA guidelines and utilizing the Web of Science database, aimed to examine the current state of this field, providing insights for future investigations. The search employed strategies with truncation techniques and Boolean operators, followed by a three-step screening using well-defined eligibility criteria.

Effective optimization of irrigation networks with pressure-driven outflows at randomly selected installation nodes.

This paper presents an innovative methodology for the design of pressurized irrigation networks. Compared to other methodologies proposed in the scientific literature, it features three novel aspects: (i) construction of peak demand scenarios based on the random selection of installation nodes for hydrant heads available in each sector of irrigated properties; (ii) realistic hydraulic modelling of outflows from hydrant heads by means of the pressure driven approach; and (iii) adoption of linear constraints to enforce the telescopic property in the distribution of diameters from the source towards the external areas of the network in the optimized design. The applications of the methodology to the real network serving an irrigated area of 750 ha in Northern Italy proved that the aspects (i) and (ii) contribute to the accurate modelling of the current network while highlighting its hydraulic deficiencies.

Comparison between Ultrasound- and Microwave-Assisted Extraction Methods to Determine Phenolic Compounds in Barley ( L.).

Barley ( L.) is one of the major cereal crops worldwide. It is grown not only to be used as fodder but also for human consumption.

Determination of Caffeoylquinic Acids Content by UHPLC in Extracts Obtained through Ultrasound-Assisted Extraction.

L., also known as golden thistle, Spanish oyster thistle or, more commonly, as tagarnina is a plant that belongs to the Asteraceae family. It is collected from the wild for human consumption in Mediterranean countries.

Characterization of BRCA Deficiency in Ovarian Cancer.

BRCA testing is recommended in all Ovarian Cancer (OC) patients, but the optimal approach is debated. The landscape of alterations was explored in 30 consecutive OC patients: 6 (20.0%) carried germline pathogenic variants, 1 (3.

Optimizing an Enzymatic Extraction Method for the Flavonoids in Moringa ( Lam.) Leaves Based on Experimental Designs Methodologies.

Lam. is known to have significant antioxidant properties. Because of this, the development of an optimal extraction method is crucial to obtain pharmacological products based on the bioactive compounds produced by this tree.

Transcriptome profiling of histone writers/erasers enzymes across spermatogenesis, mature sperm and pre-cleavage embryo: Implications in paternal epigenome transitions and inheritance mechanisms.

Accumulating evidence points out that sperm carry epigenetic instructions to embryo in the form of retained histones marks and RNA cargo that can transmit metabolic and behavioral traits to offspring. However, the mechanisms behind epigenetic inheritance of paternal environment are still poorly understood. Here, we curated male germ cells RNA-seq data and analyzed the expression profile of all known histone lysine writers and erasers enzymes across spermatogenesis, unraveling the developmental windows at which they are upregulated, and the specific activity related to canonical and non-canonical histone marks deposition and removal.

Essential Mineral Content (Fe, Mg, P, Mn, K, Ca, and Na) in Five Wild Edible Species of Mushrooms from Southern Spain and Northern Morocco: Reference to Daily Intake.

Mushroom consumption has increased in recent years due to their beneficial properties to the proper functioning of the body. Within this framework, the high potential of mushrooms as a source of essential elements has been reported. Therefore, the present study aims to determine the mineral content of seven essential metals, Fe, Mg, Mn, P, K, Ca, and Na, in twenty samples of mushrooms of the genus collected from various locations in southern Spain and northern Morocco, by FAAS, UV-Vis spectroscopy, and ICP-OES after acid digestion.

Nonlinear behavior of the impedance spectrum of a kerosene based ferrofluid.

We investigate the nonlinear behavior of the electric impedance of a kerosene-based ferrofluid (FF) sample subjected to an ac electric voltage of amplitude ranging from 10 mV to 3 V in the frequency range 6.3 mHz, 100 kHz. The FF sample was inserted between two parallel gold electrodes separated by 127 μm distance.

The Kinetics of Sorption-Desorption Phenomena: Local and Non-Local Kinetic Equations.

The kinetics of adsorption phenomena are investigated in terms of local and non-local kinetic equations of the Langmuir type. The sample is assumed in the shape of a slab, limited by two homogeneous planar-parallel surfaces, in such a manner that the problem can be considered one-dimensional. The local kinetic equations in time are analyzed when both saturation and non-saturation regimes are considered.

The effect of ripening on the capsaicinoids composition of Jeromin pepper (Capsicum annuum L.) at two different stages of plant maturity.

The changes of capsaicinoids in the pericarp and placenta of Jeromin pepper fruits, collected at two different stages of plant's maturity (young and adult), has been studied throughout the ripening process. This variety is used in the production of "Pimentón de La Vera" and recognized under a Protected Designation of Origin, so it is of great importance to determine their optimum harvesting time to get the most of its beneficial health effects. Capsaicinoids reached the maximum concentration on the 30th days post-anthesis (dpa) for the young plant, while in the adult plant it was later, specifically on 40th and 60th dpa for the placenta and pericarp, respectively.

Bioinformatic analysis identifies epidermal development genes that contribute to melanoma progression.

Several diagnostic and prognostic markers for melanoma have been identified in last few years. However, their actual contribution to melanoma progression have not been investigated in detail. This study was aimed to identify genes, biological processes, and signaling pathways implicated in melanoma progression by applying bioinformatics analysis.

Optimization through a Box-Behnken Experimental Design of the Microwave-Assisted Extraction of the Psychoactive Compounds in Hallucinogenic Fungi ().

Hallucinogenic fungi, mainly those from the genus, are being increasingly consumed even though there is no control on their culture conditions. Due to the therapeutic potential as antidepressants and anxiolytics of the alkaloids that they produce (psilocin and psilocybin), some form of control on their production would be highly recommended. Prior to identifying their optimal culture condition, a methodology that allows their study is required.

ROR2 promotes epithelial-mesenchymal transition by hyperactivating ERK in melanoma.

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a protein with important functions during embryogenesis that is dysregulated in human cancer. An intriguing feature of this receptor is that it plays opposite roles in different tumor types either promoting or inhibiting tumor progression. Understanding the complex role of this receptor requires a more profound exploration of both the altered biological and molecular mechanisms.

Extraction of Antioxidant Compounds from Onion Bulb ( L.) Using Individual and Simultaneous Microwave-Assisted Extraction Methods.

Despite the excellent beneficial properties that anthocyanins and total phenolic compounds give to the red onion bulbs, few articles have investigated modern extraction techniques or experimental designs in this field. For this reason, the present study proposes the development and optimization of alternative methods for the extraction of these compounds based on microwave-assisted extraction and the Box-Behnken experiment design. The optimal values for the extraction of total anthocyanins have been established at 62% methanol composition as a solvent, pH 2, 56 °C temperature, and 0.

A comparison study between ultrasound-assisted and enzyme-assisted extraction of anthocyanins from blackcurrant ( L.).

Blackcurrant ( L.) is a fruit rich in vitamins, fatty acids, minerals, essential oils and phenolic compounds, including anthocyanins. In the present work, two anthocyanin extraction methods from blackcurrant samples based on Ultrasound-Assisted Extraction (UAE) and Enzyme-Assisted Extraction (EAE) have been developed.

ROR2 increases the chemoresistance of melanoma by regulating p53 and Bcl2-family proteins via ERK hyperactivation.

Background: ROR2 is a tyrosine-kinase receptor whose expression is dysregulated in many human diseases. In cancer, ROR2 stimulates proliferation, survival, migration, and metastasis, and is associated with more aggressive tumor stages. The purpose of this work is to study the role of ROR2 in the chemoresistance of melanoma.

Ions, adsorption and electric response of a ferrofluid cell.

We show that the electric response of a cell in the shape of a slab containing a ferrofluid (magnetic particles in kerosene) can be interpreted by means of a model based on the adsorption of ions from limiting surfaces. We report on three samples, identical in all aspects, but limited by electrodes in gold, platinum and titanium. For frequency larger than 1 kHz, the spectra of the real and imaginary parts of the total electrical impedance of the cells are identical.

Development of Optimized Ultrasound-Assisted Extraction Methods for the Recovery of Total Phenolic Compounds and Anthocyanins from Onion Bulbs.

L. is one of the most abundant vegetable crops worldwide. In addition to its versatile culinary uses, onion also exhibits quite interesting medicinal uses.

ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation.

Background: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a Wnt5a receptor aberrantly expressed in cancer that was shown to either suppress or promote carcinogenesis in different tumor types. Our goal was to study the role of ROR2 in melanoma.

Methods: Gain and loss-of-function strategies were applied to study the biological function of ROR2 in melanoma.

Paracetamol and Ibuprofen in the Treatment of Fever and Acute Mild-Moderate Pain in Children: Italian Experts' Consensus Statements.

Fever and pain are challenging symptoms in children and adolescents and are common reasons for consultations in primary care and hospital. Paracetamol and ibuprofen are currently the only recommended drugs for treating fever in Italy, but the therapeutic approaches are discrepant in the different settings. In Italy, paracetamol and ibuprofen are the most prescribed analgesics for acute mild-moderate pain in children; however, their use is often inappropriate in that fever is over-treated and pain is under-treated.

A Novel Ultrasound-Assisted Extraction Method for the Analysis of Anthocyanins in Potatoes ( L.).

Purple potato is one of the least known and consumed potato varieties. It is as rich in nutrients, amino acids and starches as the rest of the potato varieties, but it also exhibits a high content of anthocyanins, which confer it with some attractive health-related properties, such as antioxidant, pain-relieving, anti-inflammatory and other promising properties regarding the treatment of certain diseases. A novel methodology based on ultrasound-assisted extraction has been optimized to achieve greater yields of anthocyanins.

A Methodology Based on FT-IR Data Combined with Random Forest Model to Generate for the Characterization of High-Quality Vinegars.

Sherry wine vinegar is a Spanish gourmet product under Protected Designation of Origin (PDO). Before a vinegar can be labeled as Sherry vinegar, the product must meet certain requirements as established by its PDO, which, in this case, means that it has been produced following the traditional solera and criadera ageing system. The quality of the vinegar is determined by many factors such as the raw material, the acetification process or the aging system.

Optimization of an Ultrasound-Assisted Extraction Method for the Analysis of Major Anthocyanin Content in Flowers.

plants have been used in infusions and folk medicine for years for its diuretic and antiseptic properties and even for the treatment of infections. In addition, a recently published thorough study on this species has demonstrated its antioxidant, antibiotic, anti-inflammatory, anticarcinogenic and even antitumoral activities. These properties have been associated with the high content of anthocyanins in leaves and flowers.