Putative anxiolytic-like behavioral effects of acute paracetamol in adult zebrafish.

Typically triggered by stress, anxiety disorders are most common and widespread mental illnesses. The zebrafish (Danio rerio) is rapidly becoming an important aquatic model species in stress research and central nervous system (CNS) drug screening. Paracetamol is currently the most prescribed medication for pain and fever, and is among the most used drugs globally.

Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish.

Estradiol (17β-estradiol, E) is a crucial estrogen hormone that regulates sexual, cognitive, social and affective behaviors in various species. However, complex central nervous system (CNS) effects of E, including its activity in males, remain poorly understood. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model system in translational neuroscience research.

An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish.

Background: A potent acetylcholinesterase inhibitor, donepezil is a cognitive enhancer clinically used to treat neurodegenerative diseases. However, its complete pharmacological profile beyond cognition remains unclear. The zebrafish () is rapidly becoming a powerful novel model organism in neuroscience and central nervous system drug screening.

Melatonin treatment reverses cognitive and endocrine deficits evoked by a 24-h light exposure in adult zebrafish.

Melatonin is an important pineal hormone that regulates human and animal circadian rhythms and sleep. Mounting clinical and rodent evidence indicates that melatonin also modulates affective behaviors and cognition. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model organism in translational neuroscience research.