NMDA Receptor Hypofunction in the Aging-Associated Malfunction of Peripheral Tissue.

Glutamatergic transmission through NMDA receptors (NMDARs) is important for the function of peripheral tissues. In the bone, NMDARs and its co-agonist, D-serine participate in all the phases of the remodeling. In the vasculature, NMDARs exerts a tonic vasodilation decreasing blood perfusion in the and the filtration rate in the renal glomerulus.