Typical and atypical pituitary adenomas: a single-center analysis of outcome and prognosis.

Background And Objective: In 2004, the World Health Organization defined atypical pituitary adenomas as those with a Ki-67 expression > 3%, an excessive p53 expression and increased mitotic activity. As the usefulness of this classification is controversial, we reviewed typical and atypical pituitary adenomas to compare the clinical and prognostic features.

Patients And Methods: We retrospectively reviewed 343 consecutive pituitary adenomas.