Real-world treatment and retreatment patterns and outcomes in patients with advanced or metastatic non-small cell lung cancer following nivolumab monotherapy in second line or later in France: an I-O Optimise analysis.

Introduction: This study describes treatment and retreatment patterns and outcomes in patients in France following nivolumab as a second-line or later (2L+) treatment in locally advanced or metastatic non-small cell lung cancer (LAM NSCLC).

Materials And Methods: This analysis included adults with tumor, node, metastasis stage IIIB-IV NSCLC (as defined in the 7th or 8th edition American Joint Committee on Cancer/Union for International Cancer Control) treated with nivolumab monotherapy in 2L+ using data from the retrospective Epidemiological-Strategy and Medical Economics Lung Cancer database. The inclusion period was from January 1, 2015, to September 30, 2020, with a follow-up until September 30, 2021.

A Gradient of Hippocampal Inputs to the Medial Mesocortex.

Memory-guided decisions depend on complex interactions between the hippocampus (HIPP) and medial mesocortical (MMC) regions, including the anterior cingulate (CG) and retrosplenial (RSC). The functional circuitry underlying these interactions is unclear. Using anatomy, electrophysiology, and optogenetics, we show that such circuitry is characterized by a functional-anatomical gradient.