Publications by authors named "Barbara P Gonzalez-Garcia"
Background: Celiac disease (CeD) is an immune-mediated disorder that develops in genetically predisposed individuals upon gluten consumption. HLA risk alleles explain 40% of the genetic component of CeD, so there have been continuing efforts to uncover non-HLA loci that can explain the remaining heritability. As in most autoimmune disorders, the prevalence of CeD is significantly higher in women.
View Article and Find Full Text PDFBackground: Celiac Disease (CeD) is an autoimmune disorder triggered by gluten intake in genetically susceptible individuals. Highest risk individuals are homozygous for the Human Leucocyte Antigen (HLA) DQ2.5 haplotype or DQ2.
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- Recent research indicates that the placenta plays a significant role in neurodevelopment and may contribute to the onset of neuropsychiatric disorders later in life.
- A new placental methylation quantitative trait loci (mQTL) database was created, incorporating data from 368 fetal placenta samples to explore the genetic ties between placental DNA methylation and neuropsychiatric disorders using advanced statistical methods.
- Findings suggest that certain genetic risks for schizophrenia, bipolar disorder, and major depressive disorder may be linked to DNA methylation activity in the placenta, influencing gene expression associated with these disorders.
Endometriosis is a common gynecological disorder that has been associated with endometrial, breast and epithelial ovarian cancers in epidemiological studies. Since complex diseases are a result of multiple environmental and genetic factors, we hypothesized that the biological mechanism underlying their comorbidity might be explained, at least in part, by shared genetics. To assess their potential genetic relationship, we performed a two-sample mendelian randomization (2SMR) analysis on results from public genome-wide association studies (GWAS).
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