Publications by authors named "Barbara Oliveira-Vieira"
Article Synopsis
- CTL differentiation is influenced by the interaction between various transcription factors and epigenetic modifiers, which is important for enhancing immunotherapy.
- Cbx4, a component of the polycomb repressive complex 1, promotes effector CTL differentiation in mice; its absence leads to characteristics of memory T cells and a rise in memory CTL numbers during viral infections.
- The study reveals that Cbx4 primarily regulates CTL differentiation through SUMOylation, with a secondary role involving its ability to bind to specific chromatin modifications.
CD8 T cells play a crucial role in immune responses to virus infections and tumors. Naïve CD8 T lymphocytes after TCR stimulation undergo differentiation into CTLs and memory cells, which are essential sources of IFN-γ. We investigated IFN-γ production by CD8 T cell subsets found in nonimmune mice.
View Article and Find Full Text PDFThe IRF2BP2 (IFN regulatory factor 2 binding protein 2) protein was identified as a nuclear protein that interacts with IFN regulatory factor 2 (IRF-2) and is an IRF-2-dependent transcriptional repressor. IRF2BP2 belongs to the IRF2BP family, which includes IRF2BP1, IRF2BP2, and IRF2BPL (EAP1). Recently, IRF2BP2 has emerged as an important new transcriptional cofactor in different biological systems, acting as a positive and negative regulator of gene expression.
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