Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate.

The CDH1 gene plays an important role during carcinogenesis and craniofacial morphogenesis. Germline mutations in this gene have been described in families presenting syndromic diffuse gastric cancer and orofacial clefts. The aim of this study was to evaluate the association between nucleotide variants of CDH1 and the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P).

Lack of association of polymorphic variants of genes encoding zinc transporters with the risk of orofacial cleft-affected pregnancies.

Maternal zinc deficiency seems to be a risk factor for orofacial clefts in offspring. This study was undertaken to investigate the involvement of polymorphic variants of genes for zinc transporters in the susceptibility of clefting. PCRRFLP analysis was used to analyze single nucleotide polymorphisms of SLC30A1 (rs7526700, rs2278651, rs611386), SLC30A4 (rs2453531, rs8029246), SLC30A5 (rs351444, rs164393, rs6886492), SLC39A1 (rs10127484, rs11264736), and SLC39A3 (rs759071, rs4806874, rs10415622) in mothers of children with non-syndromic cleft lip with or without cleft palate (CL/P) and control mothers.

Craniofacial morphology in complete unilateral cleft lip and palate patients consecutively treated with 1-stage repair of the cleft.

Objective: To retrospectively evaluate the craniofacial morphology of children with a complete unilateral cleft lip and palate treated with a 1-stage simultaneous cleft repair performed in the first year of life.

Methods: Cephalograms and extraoral profile photographs of 61 consecutively treated patients (42 boys, 19 girls) who had been operated on at 9.2 (SD, 2.

[Preconceptional cigarette smoking and other risk factors for giving birth to a child with orofacial cleft].

Evidence suggests an association between orofacial clefts and maternal smoking, common cold, and stressful life events. 247 mothers of children with an orofacial cleft completed a self-administered survey with questions concerning obstetric history. Of these, 29.

[Risk factors of surgical site infection in newborn infants].

Aim Of The Study: Was to estimate the risk factors for surgical site infections (SSJ) in the newborn infants.

Materials And Methods: We retrospectively analyzed medical records of 381 operated newborn infants in order to estimate the rate of SSI and risk factors. All types of operations were divided according to contamination of surgical wound /CDC classification: clean, clean-contaminated, contaminated and dirty infected/.