Risk-reducing surgeries for breast cancer in Brazilian patients undergoing multigene germline panel: impact of results on decision making.

Purpose: To assess the behavior change of high-risk breast cancer patients regarding the intention to undergo risk-reducing mastectomies (RRM) before and after genetic testing results and to identify the main influencing factors in decision-making.

Methods: Prospective cohort study conducted between November 2021 and October 2022 with women under follow-up at the high-risk outpatient clinic of the State University of Campinas (UNICAMP). Patients were referred for genetic testing, followed by counseling according to the test result.

Differences in breast cancer survival and stage by age in off-target screening groups: a population-based retrospective study.

Background: Age is an important prognostic factor in breast cancer. The target age to screen is under debate.

Objective: This study aimed to assess the influence of age on the diagnosis and survival among women with breast cancer.