Publications by authors named "Barbara M Hugrass"
Article Synopsis
- Porphyromonas gingivalis is a key bacteria associated with chronic periodontitis, relying on host sources for essential porphyrins like haem due to its inability to synthesize them.*
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- The bacterium produces a protein called HusA under iron-limited conditions, which allows it to uptake necessary porphyrins by binding them in a unique way that doesn't follow typical iron coordination patterns.*
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- Researchers developed a targeted treatment using a conjugate of deuteroporphyrin and metronidazole, taking advantage of HusA's binding properties to effectively kill intracellular P. gingivalis using a Trojan horse approach.*
