Publications by authors named "Barbara Jonson Bartikoski"
Background: Sarcopenia is a muscle disease characterized by reduction of muscle strength and muscle mass. In RA, 25.9 to 43.
View Article and Find Full Text PDFArticle Synopsis
- Morphometry of striated muscle fibres is important for assessing muscle health, and this study used the MusMA tool to analyze muscle function in two models: collagen-induced arthritis for skeletal muscle and non-alcoholic fatty liver disease for cardiac muscle.
- After studying muscle segments stained with specific dyes, researchers classified muscle fibres into various categories, revealing links between fibre types and functional performance measures such as walking speed and grip strength.
- The findings indicate that normal muscle fibres are associated with better physical function and lower cardiovascular risks, suggesting that MusMA could be a valuable tool in diagnosing muscle diseases and researching their functional implications.
Article Synopsis
- Rheumatoid arthritis is a disease that affects the muscles and can make it hard to move; this study looked at how two treatments help with this in mice.
- Mice with arthritis were given either etanercept or methotrexate, and researchers found that etanercept did a better job at keeping muscle weight normal.
- Results showed that etanercept kept muscle proteins at healthy levels, while methotrexate didn't help as much, and both treatments slowed the disease down.
The muscle fiber morphometric analysis (MusMA) is a protocol to segment and characterize the morphometry of individual cross-sectioned striated muscle fibers. Using a semi-automated Excel spreadsheet, the protocol allows the objective measurement of muscle fibers' subpopulations, aiming to characterize physiopathological conditions related to muscle tissue. The main limitation of MusMA is the need for high-quality tissue slides and images and control samples to set up the analyses.
View Article and Find Full Text PDFIntroduction/objectives: Clinical evidence of skeletal muscle involvement is not uncommon in systemic lupus erythematosus (SLE). Because of the poor understanding of signaling pathways involved in SLE muscle wasting, the aim of this study was to evaluate the effects of vitamin D supplementation on skeletal muscle in mice with pristane-induced lupus.
Methods: Balb/c mice with lupus-like disease induced by pristane injection were randomized into three groups: pristane-induced lupus (PIL; n = 10), pristane-induced lupus + vitamin D supplementation (PIL + VD; n = 10) and healthy controls (CO; n = 8).
A Review of Metabolomic Profiling in Rheumatoid Arthritis: Bringing New Insights in Disease Pathogenesis, Treatment and Comorbidities.
Metabolites
April 2022
Metabolomic analysis provides a wealth of information that can be predictive of distinctive phenotypes of pathogenic processes and has been applied to better understand disease development. Rheumatoid arthritis (RA) is an autoimmune disease with the establishment of chronic synovial inflammation that affects joints and peripheral tissues such as skeletal muscle and bone. There is a lack of useful disease biomarkers to track disease activity, drug response and follow-up in RA.
View Article and Find Full Text PDF