Publications by authors named "Barbara Hennlich"
Article Synopsis
- The ELIMINATE project aimed to reconnect individuals in Eastern Austria with previously documented hepatitis C virus (HCV) infections to medical care, supporting global elimination goals set by the WHO.
- Researchers reviewed lab records from 2008 to 2020, identifying 5,695 individuals, but faced challenges such as 34% having died and 13% lacking contact information.
- Ultimately, they successfully contacted 617 individuals, leading to a 64.3% treatment initiation rate, and confirmed an HCV cure in 326 people, demonstrating the effectiveness of targeted outreach strategies in addressing HCV.
Article Synopsis
- The study aimed to use existing laboratory records to identify and treat individuals with hepatitis C virus (HCV) viremia, assisting in broader global elimination efforts.
- Out of 22,682 individuals who tested for HCV-RNA, 6006 had detectable viremia; barriers like invalid contact information hindered follow-up, but efforts led to successful treatment initiation in some.
- This interim report from the ELIMINATE project highlights the potential of systematic screening and recall, identifying a significant number of people previously lost to care who began antiviral treatment.
Background: Among patients with ulcerative colitis, 30-50% receive corticosteroids within the first five years after diagnosis. We aimed to reconsider their effectiveness in the context of the biologic era.
Methods: In this prospective, multicenter study, patients with active ulcerative colitis (Lichtiger score ≥ 4) were eligible if initiating systemic corticosteroids.
Background: Corticosteroids are used for induction of remission in patients with moderately to severely active ulcerative colitis. However, up to one-third of patients fail to this therapy. We investigated if fecal microbial composition or its metabolic capacity are associated with response to systemic corticosteroids.
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- Ulcerative colitis (UC) is a chronic condition with increasing prevalence and uncertain causes, and advanced molecular profiling may reveal important insights into its mechanisms and remission features.
- The study involved analyzing tissue and plasma samples from UC patients using mass spectrometry to identify changes in proteins and metabolites during active disease and remission, compared to healthy individuals.
- Results showed that inflammation involved various immune cells and indicated ongoing microvascular damage and platelet abnormalities even during remission, suggesting persistent molecular markers associated with UC.
Article Synopsis
- Portal hypertension (PH) is a significant issue in liver cirrhosis, leading to serious complications like variceal bleeding, but physicians' knowledge of treatment guidelines is limited.
- Two surveys were conducted among Austrian gastroenterologists to assess their understanding of variceal management and the use of albumin, finding mixed adherence to recommendations.
- Results revealed a tendency for overtreatment, with 30% recommending unnecessary follow-up procedures, while most specialists were unclear on correct indications for early interventions and demonstrated inconsistencies in albumin dosage adherence for various conditions.