Publications by authors named "Barbara Haemmerle"
The Cullin-3 E3 ligase adaptor protein SPOP targets proteins for ubiquitination and proteasomal degradation. We previously established the β-cell transcription factor (TF) and human diabetes gene PDX1 as an SPOP substrate, suggesting a functional role for SPOP in the β cell. Here, we generated a β-cell-specific deletion mouse strain ( ) and found that is necessary to prevent aberrant basal insulin secretion and for maintaining glucose-stimulated insulin secretion through impacts on glycolysis and glucose-stimulated calcium flux.
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- Glucose is crucial for pancreatic β cell function and understanding how it influences these cells could lead to new treatments for type 2 diabetes (T2D).
- The RNA-binding protein PCBP2 is essential for β cell function, especially during high glucose conditions, as it helps regulate insulin secretion and the expression of related genes.
- Research shows that PCBP2 levels increase in response to glucose but decrease in T2D patients, linking it to gene changes that are important for β cell activity and overall insulin regulation.