Novel anti-c-Mpl monoclonal antibodies identified multiple differentially glycosylated human c-Mpl proteins in megakaryocytic cells but not in human solid tumors.

Thrombopoietin and its cognate receptor, c-Mpl, are the primary molecular regulators of megakaryocytopoiesis and platelet production. To date the pattern of c-Mpl expression in human solid tumors and the distribution and biochemical properties of c-Mpl proteins in hematopoietic tissues are largely unknown. We have recently developed highly specific mouse monoclonal antibodies (MAb) against human c-Mpl.

Hope and coping in patients with cancer diagnoses.

This descriptive correlational study explored hope and coping in patients with various cancer diagnoses. Four groups of patients with gastrointestinal/ genitourinary, breast, head and neck, or hematologic malignancies completed the Herth Hope Scale, the Jalowiec Coping Scale, and a basic demographic form. Subjects were recruited from the oncology outpatient clinic of a large mid-Atlantic teaching institution.

Multiple myeloma and its treatment.

Mr. F received several different treatment regimens for MM. He required a cardioprotectant, dexrazoxane, to continue treatment with the VAD regimen.