Reversible Dilated Cardiomyopathy Associated With Herpes Simplex Virus Infection: A Case Report.

Dilated cardiomyopathy (DCM) is a serious condition often leading to acute heart failure (HF), with diverse etiologies including viral myocarditis. This report details a case of reversible DCM in a 34-year-old male who presented with symptoms of acute HF. Diagnostic workup revealed biventricular dilation with severe systolic dysfunction and serology confirming herpes simplex virus infection.

Between neurons and networks: investigating mesoscale brain connectivity in neurological and psychiatric disorders.

The study of brain connectivity has been a cornerstone in understanding the complexities of neurological and psychiatric disorders. It has provided invaluable insights into the functional architecture of the brain and how it is perturbed in disorders. However, a persistent challenge has been achieving the proper spatial resolution, and developing computational algorithms to address biological questions at the multi-cellular level, a scale often referred to as the mesoscale.

Host Transcriptional Meta-signatures Reveal Diagnostic Biomarkers for Plasmodium falciparum Malaria.

Background: Transcriptomics has been used to evaluate immune responses during malaria in diverse cohorts worldwide. However, the high heterogeneity of cohorts and poor generalization of transcriptional signatures reported in each study limit their potential clinical applications.

Methods: We compiled 28 public data sets containing 1556 whole-blood or peripheral blood mononuclear cell transcriptome samples.

Towards Understanding Male Infertility After Spinal Cord Injury Using Quantitative Proteomics.

The study of male infertility after spinal cord injury (SCI) has enhanced the understanding of seminal plasma (SP) as an important regulator of spermatozoa function. However, the most important factors leading to the diminished sperm motility and viability observed in semen of men with SCI remained unknown. Thus, to explore SP related molecular mechanisms underlying infertility after SCI, we used mass spectrometry-based quantitative proteomics to compare SP retrieved from SCI patients to normal controls.

Differential seminal plasma proteome according to semen retrieval in men with spinal cord injury.

Objective: To evaluate protein expression profile and to quantify proteins present in seminal plasma from men with spinal cord injury (SCI) and healthy men without SCI.

Design: Experimental study.

Setting: University hospital.

Changes in the seminal plasma proteome of adolescents before and after varicocelectomy.

Objective: To compare seminal plasma protein profiles before and after varicocele correction to assess if surgical intervention alters the protein profile.

Design: Prospective study.

Setting: Academic research environment.

Proteomic analysis of follicular fluid from women with and without endometriosis: new therapeutic targets and biomarkers.

Endometriosis is a gynecological disease that affects women of reproductive age. The protein profiles of women with endometriosis who were able or unable to achieve pregnancy and women without endometriosis who did achieve pregnancy were compared in this study. The follicular fluid was collected from 21 patients undergoing in vitro-fertilization treatment, according to the following groups: nine women in the control group (Group C), four women with endometriosis who achieved pregnancy (Group E.

Adolescent varicocele: improved sperm function after varicocelectomy.

Objective: To assess the effect of varicocelectomy on sperm function (DNA integrity and mitochondrial activity) and levels of lipid peroxidation in seminal plasma of adolescents.

Design: Prospective study.

Setting: Patients recruited from a local public school.

Is sperm cryopreservation an option for fertility preservation in patients with spinal cord injury-induced anejaculation?

Objective: To evaluate the effects of cryopreservation on sperm mitochondrial activity and nuclear DNA integrity in men with spinal cord injury.

Design: Prospective controlled study.

Setting: Patients in an academic research environment.