Publications by authors named "Barbara Das-Neves"

Integral health encompasses the way individuals live, considering their quality of life. An inadequate lifestyle can harm human health, increasing the risk of developing chronic non-communicable diseases, which represent 71% of the causes of death worldwide and 54.7% in Brazil.

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Background: Anomalous origin of a coronary artery from the pulmonary trunk is a small group of rare congenital anomalies present in up to 1% of the population. These patients, in absence of an adequate collateral supply, may present with congestive heart failure secondary to ischaemia, arrhythmia, or sudden cardiac death in up to 90% of cases within the first months of life.

Case Summary: We present four cases diagnosed in adulthood over 10 years in two high-volume centres.

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Article Synopsis
  • Refractory angina is a significant clinical issue, and this study aimed to evaluate the safety and feasibility of injecting CD133(+) cells to promote blood vessel growth in affected patients.
  • In a randomized, double-blind trial involving 28 patients, the results showed safety for the cell injections, with some adverse events but no major differences in overall effectiveness between treatment and control groups.
  • However, patients who received the CD133(+) cell treatment experienced a notable reduction in monthly angina episodes and improved heart function as indicated by SPECT imaging, suggesting potential for further research into this therapy.
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Aims: Limited data are available on prognostic indicators for HIV patients presenting with ACS.

Methods And Results: Data on consecutive patients with HIV infection receiving standard highly active antiretroviral therapy (HAART) presenting with ACS between January 2001 and September 2012 were collected. Cardiac death and myocardial infarction (MI) were the primary end-points.

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Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreover, muscarinic cardiac autoantibodies appear to enhance parasympathetic activity on the sinus node.

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