Publications by authors named "Barbara Costa Pereira"

Animal models of cerebral ischemia have improved our understanding of the pathophysiology and mechanisms involved in stroke, as well as the investigation of potential therapies. The potential of zebrafish to model human diseases has become increasingly evident. The availability of these models allows for an increased understanding of the role of chemical exposure in human conditions and provides essential tools for mechanistic studies of disease.

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Gallic acid (GA) is a secondary metabolite found in plants. It has the ability to cross the blood-brain barrier and, through scavenging properties, has a protective effect in a brain insult model. Alcohol metabolism generates reactive oxygen species (ROS); thus, alcohol abuse has a deleterious effect on the brain.

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Alzheimer's disease (AD) is characterized by progressive impairment of memory, with an etiology involving oxidative stress and inflammation. Exercise training is a safe, efficacious, and economic approach to manage neurodegenerative diseases. In AD, the biomarkers of oxidative damage to lipids, proteins, and DNA are elevated.

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Article Synopsis
  • - The study focuses on how the tissue response to acute myocardial infarction (AMI) can lead to complications from inflammation and oxidative stress, and explores the potential of antioxidant and anti-inflammatory agents to mitigate these effects.
  • - Researchers investigated the impact of gold nanoparticles (AuNP) combined with 2-methoxy-isobutyl-isonitrile (MIBI) on heart injury and remodeling after AMI in Wistar rats, which were subjected to a temporary blockage of a coronary artery followed by reperfusion.
  • - Results showed that different concentrations of AuNP-MIBI affected oxidative stress and inflammation, indicating its potential for therapeutic use in treating heart damage caused by AMI.
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The experiments performed in this study consisted of 16 batch reactors fed different mixtures of landfill leachate combined with synthetic wastewater treated using the Powdered Activated Carbon Treatment (PACT) process. The objective was to measure the COD mass removal per liter each day for each reactor using two models: the first model combined the variables PAC concentration (0 g·L(-1), 2 g·L(-1), 4 g·L(-1), and 6 g·L(-1)) and leachate rate in the wastewater (0%, 2%, 5%, and 10%), and the second model combined the PAC concentration and the influent COD. The Response Surface Methodology with Central Composite Design was used to describe the response surface of both models considered in this study.

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