[Effect and tolerability of sequential administration of estradiol valerate and medroxyprogesterone acetate on menopausal symptoms, hormonal profile and biochemical markers in climacteric women].

Unlabelled: Hormonal replacement therapy is the gold standard in the treatment and prophylaxis of menopausal symptoms and osteoporosis.

The Aim: Of the study was to assess changes in climacteric symptoms, hormonal profile and biochemical parameters during sequential hormonal replacement therapy in climacteric women 19 women aged 46-61 years old was included into the study. We evaluated Kuppermann's index, serum concentration of estradiol, FSH, morphology of the blood, lipids and haemostatic parameters.

[Influence of a new monophasic oral contraceptive on body metabolism].

Objectives: Androgenic activity as adverse effects of oral contraception can influence on discontinuation of the therapy. New gestagens used in oral contraception do not reveal androgenic activity. The aim of the study is to assess the safety of the therapy with a new monophasic oral contraception on metabolism.