Publications by authors named "Barbara Ayumi Miura"
Article Synopsis
- Melanoma is a highly aggressive skin cancer, prompting research into new treatments, including the use of solamargine, a plant-derived alkaloid.
- The study tested solamargine and its nanoparticle formulation on a melanoma mouse model, finding that solamargine significantly reduced tumor size and cell proliferation without causing noticeable toxicity.
- The research indicates that solamargine and its nanoparticle version are promising candidates for melanoma therapy, potentially offering treatment options with minimal side effects.
The aim of this study was to evaluate the antitumor efficiency of chemotherapy with cisplatin alone and incorporated into europium(III)-doped yttrium vanadate nanoparticles functionalized with 3‑chloropropyltrimethoxysilane with folic acid and without folic acid in a syngeneic mouse melanoma model. Histopathological, biochemical and genotoxic analyses of treated animals were performed to assess the toxicity of treatments. The treatment of the animals with cisplatin alone and the nanoparticles functionalized with cisplatin at a dose of 5 mg/kg b.
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