Cross-frequency interactions between frontal theta and posterior alpha control mechanisms foster working memory.

Neural oscillatory activity in the theta (4-8 Hz) and alpha (8-14 Hz) bands has been associated with the implementation of executive function, with theta in midline frontal cortex and alpha in posterior parietal cortex related to working memory (WM) load. To identify how these spatially and spectrally distinct neural phenomena interact within a large-scale fronto-parietal network organized in service of WM, EEG was recorded while subjects performed an N-back WM task. Frontal theta power increase, paralleled by posterior alpha decrease, tracked participants' successful WM performance.

Early life stress and psychiatric disorder modulate cortical responses to affective stimuli.

Altered affective processing has been proposed as mediating between early life stress (ELS) and subsequent psychopathology. The present study examined whether ELS influences affective cortical processing differently in psychiatric patients and healthy subjects. The number of stressful experiences before onset of puberty was assessed in 50 inpatients with diagnoses of Major Depressive Disorder, schizophrenia, drug addiction, or Borderline Personality Disorder and in 20 healthy comparison subjects.

Stress load during childhood affects psychopathology in psychiatric patients.

Background: Childhood stress and trauma have been related to adult psychopathology in different psychiatric disorders. The present study aimed at verifying this relationship for stressful experiences during developmental periods by screening stress load across life in adult psychiatric inpatients with different diagnoses compared to healthy subjects. In addition, a relationship between the amount of adverse experiences and the severity of pathology, which has been described as a 'building block' effect in posttraumatic stress disorder (PTSD), was explored for non-traumatic events in psychiatric disorders other than PTSD.