Publications by authors named "Barbara Ann Centeno"
Article Synopsis
- PDAC is a highly lethal cancer, and early detection methods are inadequate, although noninvasive precursors like IPMNs present an opportunity for better diagnosis and management.
- Research indicates that miRNAs play a significant role in the progression of IPMNs, leading to the hypothesis that these miRNAs could be detected in blood samples.
- A study developed a 30-miRNA signature that effectively distinguishes IPMN patients from healthy controls, and a separate 5-miRNA signature differentiates malignant IPMN cases from benign ones, suggesting the potential for a blood test to identify which patients need surgery while avoiding unnecessary treatment for benign cases.
Background: Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic ductal adenocarcinoma (PDAC) precursors. Differentiating between high-risk IPMNs that warrant surgical resection and low-risk IPMNs that can be monitored is a significant clinical problem, and we sought to discover a panel of mi(cro)RNAs that accurately classify IPMN risk status.
Methodology/principal Findings: In a discovery phase, genome-wide miRNA expression profiling was performed on 28 surgically-resected, pathologically-confirmed IPMNs (19 high-risk, 9 low-risk) using Taqman MicroRNA Arrays.