Variation of HLA class I (-A and -C) genes in individuals infected with hepatitis B or hepatitis C virus in Cameroon.

The Human Leucocyte Antigens (HLA) work in concert with other immune factors to modulate immunity to viral infections. Extensive variation has been reported in the genetic sequences and functions of classical HLA class I genes in many (mostly Western) populations, and several HLA associations with infectious disease outcomes have been reported. Little is known about their role in the susceptibility or resistance to hepatitis viruses in Central African populations.

CCR2 polymorphism and HIV: mutation in both mother and child is associated with higher transmission.

C-C motif chemokine receptor 2 (CCR2) is one of the co-receptors of HIV found on the surface of the target cell and studied as genetic factors known to be associated with HIV infection. This study investigates the influence of mothers' and children's CCR2 polymorphism on HIV acquisition in children. A cross-sectional study was performed in five hospitals in the Northern Region of Cameroon.