[Effect of fluvastain and its combination with aspirin and trental on hemostasis and microcirculation in atherosclerosis].

Aim: To assess effects of fluvastatin monotherapy and combined therapy with aspirin and trental on hemostasis and microcirculation in atherosclerosis.

Material And Methods: Hemostasis and microcirculation were studied in 68 patients with coronary atherosclerosis and aortic atherosclerosis on fluvastatin monotherapy and on combined therapy fluvastatin + aspirin + trental.

Results: Hypolipidemic treatment with fluvastatin reduced thrombogenic blood potential due to enhancement of plasmic fibrinolytic activity [the time of XII-a dependent fibrinolysis decreased by 33% (p < 0.

[Lipid and non-lipid effects of enduracin in patients with arterial hypertension].

Aim: To analyze lipid and non-lipid effects of 6-month administration of enduracine in patients with marked dislipoproteinemia suffering from arterial hypertension with ischemic heart disease or without it.

Materials And Methods: 40 hypertensive patients (27 males and 13 females, mean age 52.43 +/- 1.

[Features of individual pain sensitivity of patients with ischemic heart disease during different variants of bicycle ergometry test].

Aim: To assess the significance of individual pain sensitivity in the development of painful and painless episodes of acute myocardial ischemia.

Materials And Methods: Bicycle ergometry test was carried out in 50 patients aged 35-65 years with angina of effort, functional classes II-III. Before bicycle ergometry, tactile and pain sensitivity thresholds and duration of pain tolerance were assessed by SSM-01 sensometer.

[The use of the delayed-action form of korinfar in arterial hypertension, stenocardia and hypertrophic cardiomyopathy].

Corinfar-retard (CR) was tried in 146 patients, the acute test was performed in 26 cases. The findings confirm antihypertensive activity of the drug, reduced frequency of sharp changes in blood pressure and of hypertensive crises, side effects, its ability to diminish platelet aggregation. As for coronary heart disease.

[Detection of angina pectoris in a 5-year follow-up of patients with initially diagnosed cardialgia].

During a 5-year follow-up of 150 patients with initially diagnosed cardialgia, the diagnosis of angina pectoris was revised more frequently in those followed up by therapeutists (46%), significantly more infrequently in those seen by outpatient cardiologists (18%) and much more infrequently in those examined by hospital cardiologists (6%). Risk factors for coronary heart disease were detected 2-4 times more frequently in patients with angina pectoris than in those with preserved cardialgia.

[Crystallogenic properties of serum lipid fraction in healthy persons and in patients with ischemic heart disease].

A crystallization method was proposed to assess disturbances in the lipid system; it was based on the interaction of a serum lipid fraction with a lecithin matrix. A total of 255 invidividuals were examined. A model experiment was performed by using chemically pure cholesterol (96 samples) and 10 different cholesterol esters (240 samples).

[Lipid peroxidation and hyperuricemia in patients with ischemic heart disease].

Lipid peroxidation, activity of the enzymatic link of the antioxidative system, and parameters of the lipid system were studied in 62 patients with coronary heart disease (27 patients with hyperuricemia and 35 subjects with normal uric acid levels) in relation to blood uric acid concentrations. The levels of uric acid, malonic dialdehyde, total lipids, total cholesterol, beta-lipoprotein cholesterol, triglycerides were measured and the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were evaluated. In the patients there was an increase in lipid peroxidation and lipid composition changes which were more drastically marked in hyperuricemia.

[Hormone and lipid interrelations in young women with normal and disturbed balance of sex steroids].

Altogether 121 patients with sclerocystic ovaries and 40 normal women aged 16 to 35 years were examined for excretion of estrogens, androgens and pregnandiol with urine and for the blood content of total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDLC) followed by hyperlipoproteinemia (HLP) phenotyping. In the group of normal women, low production of estrogens and pregnandiol was coupled with a reduction in the content of HDLC and an increase in that of TG. In the patients, no relationship was established between the changes in the concentration of estrogens and pregnandiol and the lipid content.

[Effectiveness of the physical training of post-myocardial infarction patients with differing exertion tolerances].

A total of 159 men after myocardial infarction were examined. Of them 73 were engaged in physical training for 11 mos. Its efficacy was analysed after the results of bicycle ergometry taking account of initial exercise tolerance.

[Serum apolipoproteins A-1 and B in young males with a history of myocardial infarction].

The content of the protein-lipid components of lipoproteins of individual classes was studied in 87 coronary heart disease patients surviving myocardial infarction under 40 years of age. All the patients lived in Sverdlovsk. The control group was made up of 49 age-matched males without any symptoms of CHD.

[Cardiovascular disorders, autonomic disorders and atherogenic dyslipoproteinemias in young women with the sclerotic ovary syndrome].

The authors studied 158 young women with the syndrome of sclerocystic ovaries (SCO) and 40 healthy subjects. The patients showed a high rate of vegetovascular dystonia, predominantly according to the hyperparasympathicotonic type, cardialgia and dyspnea. In 54.

[Clinical and instrumental characteristics of idiopathic hypertrophic cardiomyopathy and dynamics of echocardiographic indices as affected by beta-adrenergic blockaders].

Clinical investigation of 31 patients with idiopathic hypertrophic subaortal stenosis (IHSS) and idiopathic hypertrophic nonobstructive cardiomyopathy (IHNCMP) comprised electro- and phonocardiography, roentgenologic examination and echocardiography. The disease was latent in 3 patients, and ischemic heart disease or rheumatic heart lesion had been diagnosed prior to echocardiography in 26. Asymmetrical hypertrophy and hypokinesia of the upper third of the ventricular septum, narrowed left-ventricular cavity and septum-wise systolic movement of the anterior mitral cusp were findings common to all IHSS patients.

[Immunological reactions to lipoproteins and heparin in young men with a hereditary tendency to arteriosclerosis].

Among young men with hereditary tendency to atherosclerosis one frequently finds immunological reactions to serum lipoproteins of very low density, somewhat less frequent reactions to heparin are encountered. Possible mechanisms of actions of antibodies to lipoproteins and heparin are discussed.

[Serial echocardiographic studies of the function of the left ventricle in acute myocardial infarct].

The results of serial echocardiographic examination of 51 patients with primary myocardial infarction are discussed. Echocardiography was performed on the 1st, 3rd, 5th, 7th, 10th, and 20th days of the disease and before discharge. Thirty patients had infarct of the anterior wall and 21 of the posterior wall.