NEUROPROTECTIVE AND ANTIOXIDANT POTENTIAL OF MONTELUKAST-ACETYLCYSTEINE COMBINATION THERAPY FOR BRAIN PROTECTION IN PATIENTS WITH COVID-19 INDUCED PNEUMONIA.

Direct critical attack of the coronavirus on the alveoli and the excessive release of a large number of cytokines (IL-6, IL-1, TNF-α, etc.) provides suitable conditions for the further development of acute respiratory distress syndrome (ARDS) and severe acute respiratory failure. Serious decrease in blood oxygenation often lead to the deterioration of macro- and microcirculation, irreversible brain damage and hence, persistent neurological and mental disorders despite background intensive therapy and adequate respiratory support.

[EVALUATION OF NEUROPROTECTIVE ACTIVITY OF COMPLEX IMPACT OF MAGNESIUM OF SULFATE, LAMOTRYGINE AND N-ACETYLCYSTEINE UNDER CONDITIONS OF COMBINED NORMOBARIC HYPOXIA WITH LIGATION OF RIGHT CAROTID ARTERY IN RATS].

Cerebrovascular diseases of ischemic origin still remain the leading cause of death and disability of the population. In acute cerebral discirculation conditions, anaerobic glycolysis is activated, ATP formation rate decreases, the ion pumps work is disrupted and superoxide radicals are formed. Eventually, ionic asymmetry leads to the cytotoxic and vasogenic brain edema.

[Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)].

In this work is presented the data on the variability of the functional characteristics of the chromosomes in the cells exposed by oligopeptide bioregulator - Prostamax from old individuals (75-86 years). Evaluated: the frequency of sister chromatid exchanges (SCE); Ag-positive NORs (in associations and nonassociations), as well as the variability of the structural C-pericentromeric heterochromatin. Prostamax changed the chromosomal parameters: 1) increased the frequency of SCE to 12,0±0,28 exchange in per cell (in intact cells - 5,9±0,2); 2) increased the frequency of Ag-positive NORs to 2.

Genetic changes induced by the pesticide Ridomol in the soybeans sprouted from the seeds of different ages.

An objective of presented study was to investigate the effect of the genetically active xenobiotics Ridomili on the genetic apparatus of the plants sprouted from the soybean seeds of different ages. The experiments were conducted on the soybean (Glycine max) genetic line L65-1237. The studies were performed on the 1-, 2- or 3- year old seeds of the heterozygous Y(11)y(11) plants.

[Gastroprotective properties of phytomedicine tiol].

Phitopreparation tiol is offered (5% fatty solution of Tea Leaf lipid complex) as a medicine. To determine gastroprotective effect of tiol generally accepted models of acute gastric ulcer were used: bitadion, atopanove and reserprinove stomach damages. An experiment was conducted on half-matured white mice weighting 140-160 g.

[Healing activity of the oil extract of tea leaf].

At the department of organic chemistry and chemical technology oil extraction of tea leaf has been received (conditionally EM ChL). Pharmacological action of the medicine EM ChL has been studied on the models of linear and plane wounds, thermal and chemical burns of a skin in white rats. As a drug of comparison Aekol has been used in the comparable doses according to the recommendations of pharmacological committee (registration number 87/295/3).

[Dynamics of restoration of the motor and sensory functions of the upper extremity after suturing].

In 46 patients 63 nerves of upper extremities were sutured and clinico-electroneuromyographic investigations performed. The restitution of motor and sensory functions ran slowly over 7 to 36 months depending on the level injured. Full restoration of motor functions surpassed the restoration of sensory functions in the autonomic zone of the nerve lesioned.

[Diagnostic value of electromyography in revealing the laterality of the motor deficit in brain tumors].

Electromyographic studies of anterior tibial muscles supplemented by simultaneous induction of Babinski's reflex indicated the appearance of bioelectrical activity in the extremities contralateral to the tumour which suggested the generalization of tone alterations and helped determine the laterization of the pathological process even when there were no clinical manifestations of motor deficit. Having analyzed their own and literature data, the authors came to the conclusion that the contralateral response observed on the electromyogram in the form of prolonged bioelectrical activity with simultaneous appearance of tonic tension in the crus flexors in the absence of clinically evident motor deficit is explained by the presence of the crossover protective reflex on the spinal level.