Int J Environ Res Public Health
June 2020
The Pathways and Resources for Engagement and Participation (PREP), an environmental-based intervention, is effective in improving the participation of youth with disabilities in specific targeted activities; however, its potential impact on overall participation beyond these activities is unknown. This study examined the differences in participation levels and environmental barriers and supports following the 12-week PREP intervention. Existing data on participation patterns and environmental barriers and supports, measured by the Participation and Environment Measure for Children and Youth, pre-and post-PREP intervention, were statistically analyzed across 20 youth aged 12 to 18 (mean = 14.
View Article and Find Full Text PDFBackground: Documentation of information in the health record by pharmacists is vital to patient care. Failure to document, or failure to document appropriately, may have negative effects on patients.
Objectives: The primary objective was to determine pharmacists' competency in 18 elements of chart note documentation at 2 tertiary care centres and 1 rehabilitation centre.
New legal provisions have changed the rules of production, import and use of chemicals in the European Union Member States. Chemical substances present on the common market are covered by registration duty. Manufacturers and importers of substances are obliged to ensure that the risk posed by a given substance is adequately controlled on each stage.
View Article and Find Full Text PDFBackground: Health and safety at work is frequently perceived as a domain to be protected exclusively against occupational hazards without taking into account socio-demographic determinants and non-occupational factors dependent on work culture and quality of life. This study aimed at evaluating the impact of socio-demographic determinants on self-assessed health status and frequency of health complaints in workers employed in a large institution as well as the perception of the influence of working conditions on their health and the occurrence of selected diseases and health complaints.
Material And Methods: The study was carried out in the entire population of employees of a large institution.
Background: To acquire information on health needs determined by the employees themselves is an essential condition for setting the objectives of the enterprise health policy. The survey serving this purpose can be performed with use of a questionnaire, which facilitates the collection of employees' opinions and judgments on their own health, their behavior r having a strong impact on health, as well as on working conditions, organization of work, social climate and potential for the professional development. The emphasis should be put on factors affecting health, the impact of which can be modified by various promotional and preventive actions at the workplace.
View Article and Find Full Text PDFBackground: Macedonia is the first country in the region to launch implementation of the WHO Health, Environment and Social Management in Enterprises (HESME) Programme, following the WHO Ministerial Conference on Environment and Health held in London in 1999.
Objectives And Methods: The aim of this paper is to describe the efforts made to implement this programme. Methods are based on integrated management with joint involvement of crucial partners at all levels of activities suggested by the WHO.
The purpose of this study was to evaluate the efficacy and toxicity of the preparative regimen of thiotepa and etoposide in patients undergoing autologous transplantation for relapsed non-Hodgkin's lymphoma. The study involved 65 consecutive patients who underwent autologous transplantation using the thiotepa/etoposide regimen for relapsed intermediate-grade NHL at the University of Wisconsin Hospital and Clinics (UWHC) between 1987 and 2001. The regimen consisted of thiotepa 300 mg/m(2)/day and etoposide 700 mg/m(2)/day on days -6, -5, and -4.
View Article and Find Full Text PDFInt Arch Occup Environ Health
October 2002
This paper presents the concept and objectives of good practice in health, environment and social management in enterprises (GP HESME). Major criteria for establishing this approach and possible indicators to assess progress at the enterprise and municipal level are also outlined. Employers and employees make a huge number of decisions at work which have an influence on the use of natural resources, the ambient environment, quality of living and working environment, work organization and work cultures.
View Article and Find Full Text PDFInt J Occup Med Environ Health
October 2002
The author lists the main objectives, work areas and benefits of good practice in health, environment and social management in enterprises (GP HESME). History of this cross-sectoral and multidisciplinary approach to management of occupational, lifestyle, environmental and social health determinants is outlined. Health policy requirements and performance indicators are provided to facilitate GP HESME implementation at the enterprise and local levels.
View Article and Find Full Text PDFT he goal of the study wasto evaluate the usefulness of metallothionein mRNA, anti-5- hydroxymethyl-2'-deoxyuridine antibodies titres (anti-HMdU Ab), and 8-hydroxydeoxyguanosine (8OHdG) in urine as markers of the biologically active dose after exposure to airborne cadmium and nickel in human studies. Exposed persons (n = 38) were chosen from workers involved in the production and assembly, chemistry, and maintenance departments of a nickel-cadmium battery factory in Poland. Controls (n = 52) were chosen from administration personnel at the factory.
View Article and Find Full Text PDFRecords of births from registry offices in seven provinces (Wałbrzych, Piotrków Trybunalski, Suwałki, Krosno, Rzeszów, Przemyśl, Tarnobrzeg) making four regions (south-western, central, north-eastern and south-eastern) were used for the analysis of the geographical distribution of congenital malformations. This area is inhabited by approximately 10% of the whole population with annual number of briths equal to 9% of the total number in Poland. The incidence of congenital malformations was analysed in 21.
View Article and Find Full Text PDFCancer Epidemiol Biomarkers Prev
April 1996
Expression of the metallothionein (MT) gene in frozen human lymphocytes has been developed as a new molecular biomarker of heavy metal exposure. Workers at a Polish battery factory with high exposure to cadmium were monitored for airborne exposure and blood cadmium levels. A novel quantitative reverse transcription-PCR (RT-PCR) technique, making use of a homologous internal standard, was used to assess the level of MT-specific mRNA in frozen stored aliquots of blood samples taken from exposed and control workers.
View Article and Find Full Text PDFInt Arch Occup Environ Health
February 1997
Teratog Carcinog Mutagen
January 1997
This study was performed to evaluate the effects of prenatal development of rats exposed to Polnoks R, an antioxidant in elastomer processing. Pregnant female rats were exposed to Polnoks R by gavage every day on days 6-15 of gestation at doses of 170, 340, and 670 mg/kg body weight (b,w) (6%, 13%, and 25% LD50). Clinical observations, maternal body weights, and food and water consumption were recorded throughout gestation.
View Article and Find Full Text PDFTeratog Carcinog Mutagen
November 1996
Sulfenamide TS (N-cyclohexyl-2-benzothiazolesulfenamide), accelerator of rubber vulcanization, was administered to female rats by gavage at doses of 50, 150, and 450 mg/kg (1%, 3%, and 8% of LD50) during organogenesis. The maternal toxicity of Sulfenamide TS was found at the highest dose of 450 mg/kg. Oral administration of this compound to female rats during organogenesis induced fetotoxic effects at doses of 50 mg/kg and higher.
View Article and Find Full Text PDFA mortality study was carried out among workers employed in a plant producing different kinds of dyes, including benzidine. The cohort comprised 8,523 males and 2,006 females whose vital status was recorded between Jan 1, 1945 and Dec. 31, 1991.
View Article and Find Full Text PDFA mortality study was carried out among workers employed in a plant producing different kinds of dyes using benzidine. The cohort comprised 8,523 males and 2,006 females whose vital status was recorded between Jan 1, 1945 and Dec 31, 1991. They had worked in this plant for, at least, 3 months between Jan 1, 1945 and Dec 31, 1974.
View Article and Find Full Text PDFEnviron Health Perspect
September 1994
This study was undertaken to establish whether occupational exposures to derivatives of carcinogenic metals evoke inflammatory immune responses, as determined by the presence of elevated titers of antibodies (Ab) that recognize oxidized DNA bases. Sera obtained from the blood of steel welders (Delaware) and from workers of the Centra Ni-Cd Battery Factory (Poznań, Poland) were analyzed by the enzyme-linked immunosorbent assay. To determine specific and nonspecific binding, an oxidized thymidine [5-hydroxymethyl-2'-deoxyuridine (HMdU)] coupled to bovine serum albumin (HMdU-BSA) as well as mock-coupled BSA (M-BSA) were used as antigens for coating the wells of microtiter plates.
View Article and Find Full Text PDFTwo methods of linear extrapolation from high to low doses were discussed. The first method depended on fitting a particular model (multistage, logistic) from the experimental data and then on extrapolating from the point on the dose-response curve to the lowest positive dose level employed. The linearized multistage model of carcinogenesis was used in the second method--the results obtained were highly conservative.
View Article and Find Full Text PDFPotential carcinogenic activity of alpha-aescin and phenbendasole made by "Polfa" (Poland) as well as phenbendasole produced by "Hoechst" (Germany) was studied using Salmonella/microsome test, DNA repair test and micronucleus assay. None of tested preparations were mutagenic or genotoxic what suggest that none of them possess potential carcinogenic activity. Besides, it was established that alpha-aescin exhibits strong and phenbendasol weak acute systemic toxicity for mice.
View Article and Find Full Text PDFMolecular aspects of the expression of genes responsible for coding the proteins which participate in the oxidative metabolism of polyaromatic hydrocarbons (PAH) have been discussed. Particular attention has been paid to the expression of the gene for the intracellular PAH-binding AHR protein receptor. Possible relationship between genetically-conditioned polymorphism of PAH oxidative metabolism and individual susceptibility to lung cancer has been presented.
View Article and Find Full Text PDFSmoking and consumption of fried and smoked meat play, besides occupational exposure, a significant role in the etiology of neoplasm induced by chemical carcinogens. Homo- and heterocyclic aromatic amines which are present in tobacco smoke and generate during meat processing are of special concern. Homocyclic aromatic amines are mainly responsible for inducing neoplasm of bladder while heterocyclic amines induce neoplasm of colon.
View Article and Find Full Text PDFTwo surface-active compounds, Rokanol B2 and Rokamid R1, were examined with three types of screening tests: 1. standard Ames test in vitro using S. typhimurium TA97a, TA98, TA100 and TA102 strains; 2.
View Article and Find Full Text PDFInt J Occup Med Environ Health
May 1995
Female rats were given aqueous solutions of n-butanol containing 0.24, 0.8 and 4% n-butanol (0.
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