Publications by authors named "Baranowski B"
Background: Catheter ablation is an effective therapy in the management of atrial fibrillation (AF). Left atrial appendage closure (LAAC) is an alternative to anticoagulation for stroke prevention in patients with bleeding risks.
Objectives: The purpose of this study was to assess the safety and efficacy of combining AF ablation and LAAC in a single procedure.
Growth differentiation factor 15 (GDF15) is a stress-induced cytokine that suppresses food intake and causes weight loss. GDF15 also reduces voluntary physical activity and, thus, it is not clear whether combining GDF15 with exercise will be beneficial or if reductions in food intake would be offset by decreases in physical activity. We investigated how GDF15 treatment combined with voluntary wheel running (VWR) would impact weight gain, food intake, adiposity and indices of metabolic health in mice.
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- - Growth differentiation factor 15 (GDF15) increases during exercise and is linked to higher levels of corticosterone and fat utilization, but its exact role during recovery from exercise remains unclear.
- - This study investigated how postexercise nutrient availability affects GDF15 levels and examined its relationship with corticosterone and various metabolic indicators in mice.
- - Findings showed that while GDF15, corticosterone, and certain fatty acids increased immediately after exercise, the relationships observed were not causal, as similar responses were seen in both normal and GDF15-deficient mice.
Article Synopsis
- Vascular access complications are common in catheter ablation procedures for ventricular arrhythmias, and the impact of vascular closure devices (VCDs) on these complications is unclear.
- This study analyzed 1,016 catheter ablation procedures over four years, categorizing cases based on the use of VCDs: none (manual compression), partial use, or complete use.
- Results showed that the use of VCDs, especially complete VCDs, significantly reduced the rate of vascular complications compared to manual compression and partial use of VCDs.
Article Synopsis
- BDNF (Brain-derived neurotrophic factor) influences amyloid precursor protein (APP) processing by reducing BACE1 activity and inhibiting GSK3β in the prefrontal cortex of mice.
- The study investigated the relationship between GSK3β and BDNF's regulation of BACE1 through cell culture and in vitro assays, confirming that BDNF treatment increased key signaling molecules while decreasing BACE1 activity.
- Results showed that blocking TrkB or Akt signaling negated BDNF's effect on BACE1 activity, highlighting the importance of GSK3β inhibition in this process and paving the way for targeted therapeutic strategies.
Background: The risk of ventricular arrhythmias (VAs) after cardiac resynchronization therapy (CRT) has been associated with ischemic disease/scar, sex, and possibly left ventricular mass (LVM).
Objective: The purpose of this study was to evaluate sex differences and baseline/postimplant change in LVM on VA risk after CRT implantation in patients with nonischemic cardiomyopathy and left bundle branch block.
Methods: In patients meeting the criteria, baseline and follow-up echocardiographic images were obtained for LVM assessment.
Article Synopsis
- The study investigates the effectiveness of post-ablation ventricular tachycardia (VT) inducibility through programmed ventricular stimulation (PVS) as a predictor for recurrence and survival outcomes in high-risk patients undergoing VT ablation.
- A retrospective analysis was conducted on 123 high-risk patients who underwent VT ablation, revealing no significant differences in long-term outcomes between those with no VT inducibility and other response groups.
- The findings suggest that post-ablation PVS results do not reliably predict survival or recurrence in high-risk VT ablation patients, challenging its current use as a procedural endpoint.
Introduction: Reports of comparison with procedural outcomes for implantable cardioverter defibrillator (ICD) and pacemaker (PM) transvenous lead extraction (TLE) are old and limited. We sought to compare the safety, efficacy, and procedural properties of ICD and PM TLE and assess the impact of lead age.
Methods: The study cohort included all consecutive patients with ICD and PM TLE in the Cleveland Clinic Prospective TLE Registry between 2013 and 2022.
Background: Data are lacking on patient-reported outcomes (PRO) following cryoballoon ablation (CBA) versus radiofrequency ablation (RFA). We sought to evaluate QoL and clinical outcomes of cryoballoon pulmonary vein isolation only (CRYO-PVI-ONLY) versus RFA with PVI and posterior wall isolation (RF-PVI+PWI) in a large prospective PRO registry.
Methods: Patients who underwent AF ablation (2013-2016) at our institution were enrolled in an automated, prospectively maintained PRO registry.
Objective: The superfamily of protein kinases features a common Protein Kinase-like (PKL) three-dimensional fold. Proteins with PKL structure can also possess enzymatic activities other than protein phosphorylation, such as AMPylation or glutamylation. PKL proteins play a vital role in the world of living organisms, contributing to the survival of pathogenic bacteria inside host cells, as well as being involved in carcinogenesis and neurological diseases in humans.
View Article and Find Full Text PDFBackground: Atrial fibrillation (AF) catheter ablation has become an increasingly effective and safe strategy for the management of AF. With increased safety of catheter ablation, same-day discharge (SDD) is a potential way to minimize health care resource utilization and improve patient experience.
Objective: To evaluate the safety and patient satisfaction of SDD after contemporary AF ablation.
Aims: Transvenous lead extraction (TLE) of implantable cardioverter-defibrillator (ICD) leads is considered challenging. The structure of each ICD leads is variable between manufacturer and model families. The net impact of lead family on the safety and effectiveness of TLE is poorly characterized.
View Article and Find Full Text PDFIschemic or Coronary Evaluations in Patients With Monomorphic VT Electrical Storm Undergoing VT Ablation.
JACC Clin Electrophysiol
September 2023
Background: Monomorphic ventricular tachycardia (VT) electrical storm (ES) in patients with coronary artery disease is dependent on scarred myocardium. The role of routine ischemic or coronary evaluations before ablation in patients presenting with monomorphic VT storm, without acute coronary syndrome (ACS), remains unknown.
Objectives: This study sought to assess the impact of ischemic or coronary evaluations on procedural outcomes and post-ablation mortality in monomorphic VT storm patients.
Introduction: Obesity is a well-known risk factor for atrial fibrillation (AF). We aim to evaluate the effect of baseline obesity on procedural complications, AF recurrence, and symptoms following catheter ablation (CA).
Methods: All consecutive patients undergoing AF ablation (2013-2021) at our center were enrolled in a prospective registry.
Background: Functionally related genes are well known to be often grouped in close vicinity in the genomes, particularly in prokaryotes. Notwithstanding the diverse evolutionary mechanisms leading to this phenomenon, it can be used to predict functions of uncharacterized genes.
Methods: Here, we provide a simple but robust statistical approach that leverages the vast amounts of genomic data available today.
Exercise reduces cognitive aging, neurodegeneration, and Alzheimer's disease (AD) risk. Acute exercise reduces the activity of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), the rate-limiting enzyme in the production of Aβ. However, mechanisms mediating these effects remain largely unknown.
View Article and Find Full Text PDFBackground: Ablation is used for both rhythm control and improved quality of life (QoL) in atrial fibrillation (AF). It has been suggested that young adults may experience high recurrence rates after ablation and data remain lacking regarding QoL benefits. We aimed to investigate AF ablation outcomes and QoL benefits in young adults undergoing AF ablation using a large prospectively maintained registry and automated patient-reported outcomes (PRO).
View Article and Find Full Text PDFBackground: Reports of coronary sinus (CS) lead removal include small studies with short implant durations. Procedural outcomes for mature CS leads removed with long duration implantation are unavailable.
Objective: The purpose of this study was to examine the safety, efficacy, and clinical predictors of incomplete CS lead removal by transvenous lead extraction (TLE) in a large long implant duration cardiac resynchronization therapy patient cohort.