[Hemodynamic effect of plasma DNA].

To reveal the hemodynamic effect of plasma DNA, the authors measured the concentrations of plasma DNA, the length of its molecular fragments, and hemodynamic resistance/Toms effect. The Toms effect was detected in all blood samples from 10 healthy donors and 39 patients without acute stroke caused by atherosclerosis of the head great arteries with and without arterial hypertension. There was a clear inverse relationships between the plasma concentrations of DNA which had only long-molecular fragments in healthy persons and the hemodynamic resistance of its blood flow samples.

[Effect of the nootropic agent cerebrolysin in cerebral ischemia in rats with varying behavioral reactions in the open field test].

Open field tests were made on 489 white male rats to distinguish subgroups by baseline higher nervous activity (HNA) to study the effects of cerebrolysin (EBEVE, Austria) on relationships between neuronal activity and cerebral blood supply in normal cerebral circulation (CC) and in acute brain ischemia. Local CC and EEG were measured by laser doppler flowmeter and read from the same point gauge. CC/EEG index was calculated.

[New findings concerning pathogenesis of disorders of cerebral circulation].

The data about the role of blood flow in atherosclerosis development were examined. The aim of the study was determination of hydrodynamic blood resistance and Toms effect in patients with ischemic disorders of cerebral circulation in different periods of the disease. 45 patients with atherosclerotic damages of major arteries of head were observed.

[Prognostic behavioral criteria and the characteristics of the cerebral blood flow in rats with different sensitivities to emotional stress].

In anesthetised Wistar adult male rats, a model of circulatory brain ischemia was created. A behavioural difference as well as a difference in normal focal cerebral blood flow (CBF), were revealed between rats resistant against and predisposed to emotional stress. The mortality level was 10% in former rats and 27% in latter ones.

[Diminished experimental alimentary atherogenesis under the influence of polymers that decrease the hydrodynamic resistance of the blood].

The experiments on adult rabbits have demonstrated that high-cholesterol diet given to the animals for 3 months causes a severe hypercholesterolemia and disseminated aortic lesion due to the formation of numerous fatty streaks and plaques of atherosclerotic genesis. The simultaneous intravenous injection of a special linear high molecular-weight polymer solution, which reduces hydrodynamic resistance once a week leads to a significantly less atherogenesis in the same hypercholesterolemia. The highest effect was observed in the descending portions of the aorta and just after its bifurcation, i.

[Comparative characterization of morphologic changes in animal brain after normo-, hypobaric hypoxic hypoxia and hypobaric normoxia].

In three series of experiments on 16 randomly inbred adult male rats, specific features of morphological changes in the brain were studied 3 days following the tests of animals for high- or low-resistance to hypoxic hypoxia (HH) during hypobaric HH (Series I), normobaric HH (Series II), and hypobaric normoxia (Series III). The conventional testing was found to result in changes in the rat brain, which were caused both by HH and decompression. The more sparing procedure is testing animal during normobaric HH which eliminates the impact of decompression whose damaging action was pronounced in hypobaric normoxia.

[Prognostically significant indices of the bioenergetic metabolism of the brain in experimental ischemia (a NMR spectroscopic study)].

Initial levels of phosphate brain metabolites were measured using 31P NMR spectroscopy in rats which subsequently died or survived under bilateral ligation of common carotid arteries. A multidimensional analysis was applied. In the rats which died after the brain ischemia: (1), NAD and NADH+ concentrations were much higher than those of creatine phosphate or ATP (i.

[Changes in energy metabolism in the brain in experimental cerebral ischemia of different degree of severity (nuclear magnetic resonance-spectroscopic study)].

The peculiarities of brain energy metabolism were studied in male rats before and during cerebral ischemia of various severity elicited by bilateral common carotid arteries ligation. A multidimensional analysis was applied. In the rats which died after the ischemia, the NAD + NADH+/phosphocreatine (PCr) ratio and ATP content before ligation were higher than those in the surviving group.

[Status of the "dead point" of blood flow in anastomoses of superficial cerebral arteries as affected by an acute increase of blood pressure].

Changes in pial arteries diameter and the condition of blood flow "dead point" in arterial anastomoses were established using the brain window during an acute increase of mean arterial pressure (MAP) induced by intravenous injection of norepinephrine (NE) with microcineangiography and the analysis of films and frames on a montage table and TAS ("Leitz"). During an acute increase of MAP the movement of blood flow "dead point" in anastomoses and the expansion of plasma segments occurred much more frequently than in normotension. The stabilization of blood flow "dead point" was observed at high constant MAP.

[Effect of different doses of dexamethasone on the course of brain injuries in animals sensitized to nerve tissue antigens].

The effect of different dexamethasone doses on the development of edema of the brain in its injury was studied on 79 rabbits, controls and those sensitized with the brain antigen. The local cerebral circulation and the total tissue fluid in the perifocal region of the injured grey and white matter of the rabbit's cerebral hemispheres were studied; EEG was recorded and ultrastructural study of the nervous tissue in the zone of the trauma at the level of the ultrastructures was conducted. The examination showed that dexamethasone had a favourable therapeutic effect on the course of the brain trauma in the early periods after it was inflicted; the agent reduced edema of the brain tissue, which was especially manifest in animals with altered immunological reactivity of the organism.