Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in the NEOSENTITURK-Trials MF18-02/18-03.

Background: This study aims to identify factors predicting recurrence and unfavorable prognosis in cN+ patients who have undergone sentinel lymph node biopsy (SLNB) following neoadjuvant chemotherapy (NAC).

Methods: The retrospective multi-centre "MF18-02" and the prospective multi-centre cohort registry trial "MF18-03" (NCT04250129) included patients with cT1-4N1-3M0 with SLNB+/- axillary lymph node dissection (ALND) post-NAC.

Results: A total of 2407 cN+ patients, who later achieved cN0 status after NAC and subsequently underwent SLNB, were studied.

Physically Cross-Linked PVA Hydrogels as Potential Wound Dressings: How Freezing Conditions and Formulation Composition Define Cryogel Structure and Performance.

: Hydrogels produced using the freeze-thaw method have demonstrated significant potential for wound management applications. However, their production requires precise control over critical factors including freezing temperature and the choice of matrix-forming excipients, for which no consensus on the optimal conditions currently exists. This study aimed to address this gap by evaluating the effects of the above-mentioned variables on cryogel performance.

3D Printed Drug Delivery Systems in Action-Magnetic Resonance Imaging and Relaxometry for Monitoring Mass Transport Phenomena.

The hypothesis of the study was that (1) 3D printed drug delivery systems (DDS) could be characterized in situ during drug release using NMR/MRI techniques in terms of mass transport phenomena description (interfacial phenomena), particularly for systems dealing with two mobile phases (e.g., water and low molecular weight liquid polymer); (2) consequently, it could be possible to deduce how these interfacial mass transport phenomena influence functional properties of 3D printed DDS.

A Study of the Influence of Cement Addition and Humidity on the Mechanical Strength and Microstructure of Flue Gas Desulfurization Gypsum-Cement Plasters.

Over the last 20 years, flue gas desulfurization gypsum (FGD gypsum) has become a valuable and widely used substitute for a natural raw material to produce plasters, mortars, and many other construction products. The essential advantages of FGD gypsum include its high purity and stability, which allow for better technical parameters compared to natural gypsum, and, until recently, its low price and easy availability. This FGD gypsum is obtained in the process of desulfurization of flue gases and waste gases in power plants, thermal power plants, refineries, etc.

Oropharyngeal Cancer Staging Health Record Extraction Using Artificial Intelligence.

Importance: Accurate, timely, and cost-effective methods for staging oropharyngeal cancers are crucial for patient prognosis and treatment decisions, but staging documentation is often inaccurate or incomplete. With the emergence of artificial intelligence in medicine, data abstraction may be associated with reduced costs but increased efficiency and accuracy of cancer staging.

Objective: To evaluate an algorithm using an artificial intelligence engine capable of extracting essential information from medical records of patients with oropharyngeal cancer and assigning tumor, nodal, and metastatic stages according to American Joint Committee on Cancer eighth edition guidelines.

Can 3D Printed Tablets Be Bioequivalent and How to Test It: A PBPK Model Based Virtual Bioequivalence Study for Ropinirole Modified Release Tablets.

As the field of personalized dosing develops, the pharmaceutical manufacturing industry needs to offer flexibility in terms of tailoring the drug release and strength to the individual patient's needs. One of the promising tools which have such capacity is 3D printing technology. However, manufacturing small batches of drugs for each patient might lead to huge test burden, including the need to conduct bioequivalence trials of formulations to support the change of equipment or strength.

Surface characteristics of additively manufactured CoCr and Ti6Al4V dental alloys: The effects of carbon and gold thin film coatings, and alkali-heat treatment.

This study investigates the impact of surface modifications on additively manufactured CoCr and Ti6Al4V dental alloys, focusing on surface properties. Thin film carbon (C) and gold (Au) coatings, as well as alkali-heat treatment, were applied to the high- and low-polished specimens. Scanning electron microscopy (SEM) showed that thin film coatings retained the underlying surface topography, while the alkali-heat treatment induced distinct morphological changes.

Investigation of postural sensory organization in women with and without primary dysmenorrhea in three phases of the menstrual cycle.

Background: The effects of the menstrual cycle in women with and without primary dysmenorrhea on phase-related postural sensory organization are controversial.

Research Question: This study was carried out to examine postural sensory organization in three phases of the menstrual cycle in women with and without primary dysmenorrhea and to evaluate whether there is a difference between women with/without primary dysmenorrhea in this regard.

Methods: Women aged 18-30 years were divided into two groups as primary dysmenorrhea group (PDG, n = 14) and control group (CG, n = 15).

Characterization of Collagen from Jellyfish Aurelia aurita and Investigation of Biomaterials Potentials.

Marine collagen sources are potent alternatives due to abundant yield, low pathogen infection risk, high biocompatibility, and any religious and ethical restrictions compared to terrestrial collagen sources. In this research, we aim to investigate the biomaterials potential of the collagen from Aurelia aurita, which is a native jellyfish species in the Marmara Sea. Spectroscopic techniques were used to investigate the structure of jellyfish collagen (JCol) from acid-soluble fraction and compared to Jellagen® from Rhizostoma pulmo.

Psychometric Properties and Cutoff Value of the Turkish Overactive Bladder Symptom Score.

Importance: The Overactive Bladder Symptom Score (OABSS) measures all overactive bladder (OAB) symptoms with graded answers, evaluates urgency symptoms, and reveals the subjective bladder control. However, the Turkish version and the cutoff value of the questionnaire have not yet been studied.

Objective: The aims of this study were to determine the psychometric properties of the 7-item OABSS and to estimate the cutoff value of the scale.

Effect of Portland Cement on the Selected Properties of Flue Gas Desulfurization Gypsum-Based Plasters.

The introduction of the European Union's climate change legislation and the intended use of renewable energy sources instead of fossil fuels will significantly reduce the production of flue gas desulfurization (FGD) gypsum used as the raw material for gypsum mortar plasters' production. This has forced mortar producers to look for alternative materials, including gypsum-cement composites. This work investigated the mechanical strength and linear extension of four gypsum-cement mortars with the gypsum content reduced to 30%.

Conservative Approach For The Management Of Bilateral Pneumothorax And Pneumomediastinum After Laparoscopic Totally Extraperitoneal Inguinal Hernia Repair.

Laparoscopic totally extraperitoneal inguinal hernia repair is considered a common and safe procedure. Here, we present the case of a 31-year-old male with right indirect inguinal hernia and no medical history. The patient underwent laparoscopic totally extraperitoneal inguinal hernia repair and the operation was completed successfully.

Spatially resolved polymer mobilization revisited - Three-dimensional, UltraShort Echo Time (3D UTE) magnetic resonance imaging of sodium alginate matrix tablets.

Hypothesis: Three-dimensional H UltraShort Echo Time magnetic resonance imaging (H 3D UTE MRI) of the matrix tablet made of hydrophilic polymer hydrated in heavy water (DO) will allow investigation of the hydration-induced spatiotemporal evolution of the material originally included in the matrix tablet during manufacturing (i.e., polymer chains and bound water).

Evaluation of Sysmex-UF 5000-BF Module for Sterile Body Fluids. An Alternative for Conventional Methods?

Background: Infections of cerebrospinal fluid (CSF), peritoneal and pleural fluids often result in severe morbidity and mortality. Cytometric analysis, cell count, and cell differentiation is supportive in rapid clinical decision. The aim of this study is to evaluate the performance of Sysmex UF-5000 (Sysmex Co.

Co-axial electrospinning of PLLA shell, collagen core nanofibers for skin tissue engineering.

The main functions of wound dressing biomaterials are to promote a moist environment in the wound while protecting the area from mechanical injury and microbial contamination. Furthermore, the scaffold used for skin tissue engineering must mimic epidermal and dermal layers as well as support the growth of keratinocytes and fibroblasts. In this study, PLLA (shell) and EGF-encapsulated collagen (core) nanofibers were produced by coaxial electrospinning at 25 kV potential, 12 cm collector distance, and 0.

Low-field time-domain NMR relaxometry for studying polymer hydration and mobilization in sodium alginate matrix tablets.

Sodium alginate is used in various industries, including food, pharmaceutical, and agriculture. Matrix systems, e.g.

Contributory effects of individual characteristics on pelvic floor distress in women with pelvic floor dysfunctions.

Objective: To determine individual characteristics (i.e. sociodemographic and medical, obstetric and gynecological, and musculoskeletal and anthropometric parameters) for greater pelvic floor distress (PFD).

The Reality of Hypoparathyroidism After Thyroidectomy: Which Risk Factors are Effective? Single-Center Study.

Objectives: One of the most common complications of thyroidectomy is hypoparathyroidism and that complication has a multifactorial etiology. The etiology of post-operative hypoparathyroidism is multifactorial, some factors affecting hypoparathyroidism have been revealed in the literature, and there are some conflicting results about this complication. In the present study, we aimed to evaluate pre-operative and intraoperative factors affecting development of hypoparathyroidism.

Could systemic immune inflammation index be a new parameter for diagnosis and disease activity assessment in systemic lupus erythematosus?

Purpose: Systemic immune inflammation index (SII) has been used as a marker of inflammatory status in various diseases, but its role in systemic lupus erythematosus (SLE) is unknown. We aimed to investigate the role of SII in SLE and its association with disease activity and renal involvement.

Methods: In this retrospective study, 76 patients with SLE were compared with 76 age- and gender-matched healthy control group in terms of SII, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR).

Abdominal ultrasound findings in adult patients with cystic fibrosis.

Introduction And Aims: Cystic fibrosis (CF) is a genetic disease whose gastrointestinal compromise mainly involves the pancreas, bile ducts, and liver. Our aim was to analyze abdominal ultrasound findings.

Methods: A retrospective, descriptive study was conducted on adults (patients ≥ 16 years of age) diagnosed with CF, within the time frame of 2006-2019.

The Effects of Connective Tissue Manipulation in Primary Dysmenorrhea: a Randomized Placebo-Controlled Study.

The aim of this study was to identify the effects of connective tissue manipulation (CTM) in primary dysmenorrhea (PD) in a randomized, placebo-controlled design. Thirty-eight nulliparous women with PD were randomly allocated into 3 groups: CTM (n = 13), placebo therapeutic ultrasound (US) (n = 13), and control (n = 12). The primary outcome measure was the maximum and mean menstrual pain intensity at the last menstrual period on the visual analogue scale (VAS).

Development of Composite, Reinforced, Highly Drug-Loaded Pharmaceutical Printlets Manufactured by Selective Laser Sintering-In Search of Relevant Excipients for Pharmaceutical 3D Printing.

3D printing by selective laser sintering (SLS) of high-dose drug delivery systems using pure brittle crystalline active pharmaceutical ingredients (API) is possible but impractical. Currently used pharmaceutical grade excipients, including polymers, are primarily designed for powder compression, ensuring good mechanical properties. Using these excipients for SLS usually leads to poor mechanical properties of printed tablets (printlets).

Rehydration of the sleeping chironomid, Polypedilum vanderplanki Hinton, 1951 larvae from cryptobiotic state up to full physiological hydration (Diptera: Chironomidae).

During desiccation the Polypedilum vanderplanki larva loses 97% of its body water, resulting in the shutdown of all metabolic and physiological processes. The larvae are able to resume active life when rehydrated. As dehydration process has already been largely understood, rehydration mechanisms are still poorly recognized.

Enhancing Outpatient Symptom Management in Patients With Head and Neck Cancer: A Qualitative Analysis.

Importance: Patients with head and neck cancer manage a variety of symptoms at home on an outpatient basis. Clinician review alone often leaves patient symptoms undetected and untreated. Standardized symptom assessment using patient-reported outcomes (PROs) has been shown in randomized clinical trials to improve symptom detection and overall survival, although translation into real-world settings remains a challenge.