Drug repositioning identifies salvinorin A and deacetylgedunin (DCG) enriched plant extracts as novel inhibitors of Mpro, RBD-ACE2 and TMPRRS2 proteins.

The coronavirus disease 2019 (COVID-19) has spread worldwide with severe health, social, and economic repercussions. Although vaccines have significantly reduced the severity of symptoms and deaths, alternative medications derived from natural products (NPs) are vital to further decrease fatalities, especially in regions with low vaccine uptake. When paired with the latest computational developments, NPs, which have been used to cure illnesses and infections for thousands of years, constitute a renewed resource for drug discovery.

Two mosquito larvicidal arabinofuranosidetridecanol from exudate.

Two new arabinofuranosidetridecanol, namely 1,2-tridecanediol-1--α-L-5'-acetylarabinofuranoside () and 1,2-tridecanediol-1--α-L-arabinofuranoside () together with known compound, 1,2-tridecanediol () were isolated from exudate. Compound showed larvicidal activity against (LC = 40.66 µg/mL) (LC = 22.