Molecular Detection of and the Process of Infection and Illness in Contacts of Leprosy Patients: A Systematic Review.

Various techniques have been used for the molecular identification of (). The aim of this review was to identify the relationship between the molecular presence of and the process of infection and/or illness of contact of leprosy cases. A systematic review was carried out by searching the Medical Literature Analysis and Retrieval System Online (MEDLINE), Cochrane Library, Embase, Scopus, Web of Science and the Latin American and Caribbean Health Sciences Literature (LILACS) databases in January 2024.

The oncological impact of complete transurethral resection before neoadjuvant chemotherapy in muscle-invasive bladder cancer.

Objectives: To assess the impact of cTURBT on pathologic response. Secondary endpoints involved survival and oncologic outcomes.

Methods: Tertiary centre data from patients with MIBC submitted to NAC and radical cystectomy between March 2010 and November 2022 was retrospectively analysed.

Bimodality in E. coli gene expression: Sources and robustness to genome-wide stresses.

Bacteria evolved genes whose single-cell distributions of expression levels are broad, or even bimodal. Evidence suggests that they might enhance phenotypic diversity for coping with fluctuating environments. We identified seven genes in E.

How can consumer science help the foodservice industry replace meat? A critical review.

In the pursuit of more sustainable diets, researchers have been studying ways to promote a transition from animal-based to plant-based meals in foodservice contexts by influencing participants' conscious choices through names, labels, claims, and information. This critical review found that these interventions usually mobilize only those already engaged in reducing the consumption of animal products and often only during the intervention period, failing to influence those who eat most meat or to create long-lasting effects. Analyzing the choice for vegetarian meals against meals with meat in recently published studies conducted in foodservice contexts, we argue that the transition to more sustainable diets should rely less on consumers' willpower and more on public policies and institutional measures that change the availability, price, and visibility of plant-based meals.

XbaI polymorphism in the APOB gene and its association with increased cholesterol in children and adolescents: Ouro Preto study.

Atherosclerotic vascular changes can begin during childhood, providing risk for cardiovascular disease (CVD) in adulthood. Identifiable risk factors such as dyslipidemia accelerate this process for some children. The apolipoprotein B (APOB) gene could help explain the inter-individual variability in lipid levels among young individuals and identify groups that require greater attention to prevent CVD.

The Effect of Speed Endurance Versus Core Training on The Repeated Sprint Ability of Youth Male Soccer Players - A Randomized Controlled Trial.

The effects of specific training protocols to improve repeated sprint ability are well known; however, the utility of non-specific training for this purpose is doubtful. Therefore, this study aimed to compare the effects of a specific (sport-related) vs. non-specific (general physical development) eight-week training protocol on developing or maintaining repeated sprint ability in soccer players.

Comparative life cycle assessment of non-thermal plasma for the removal of pharmaceuticals from wastewater.

Wastewater effluents are a continuous source of pharmaceuticals in water bodies, which pose a serious environmental threat to aquatic ecosystems. This work provides a comprehensive technical, environmental and cost assessments of different advanced quaternary treatments for wastewater effluents, with special focus on novel Non-Thermal Plasma technology. For this porpouse Non-Thermal Plasma, Sand Filtration + Ozonation, Ultrafiltration, Ultrafiltration + Nanofiltration and Ultrafiltration + Reverse Osmosis technologies were compared with UV disinfection-based technology.

Variation in Accelerometer-Derived Instantaneous Acceleration Distribution Curves of Elite Male Soccer Players According to Playing Position: A Pilot Study.

The incorporation of triaxial accelerometers into Global Positioning Systems (GPS) has significantly advanced our understanding of accelerations in sports. However, inter-positional differences are unknown. This study aimed to explore the variability of acceleration and deceleration (Acc) distribution curves according to players' positions during soccer matches.

Impaired Periodontitis-Induced Cytokine Production by Peripheral Blood Monocytes and Myeloid Dendritic Cells in Patients with Rheumatoid Arthritis: A Case-Control Study.

: Immune cells from rheumatoid arthritis (RA) patients display a reduced in vitro response to (), which may have functional immune consequences. The aim of this study was to characterize, by flow cytometry, the frequency/activity of monocytes and naturally occurring myeloid dendritic cells (mDCs) in peripheral blood samples from patients with periodontitis and patients with periodontitis and RA. : The relative frequency of monocytes and mDCs in the whole blood, the frequency of these cells producing TNFα or IL-6 and the protein expression levels for each cytokine, before and after stimulation with lipopolysaccharide (LPS) from plus interferon-γ (IFN-γ), were assessed by flow cytometry, in peripheral blood samples from 10 healthy individuals (HEALTHY), 10 patients with periodontitis (PERIO) and 17 patients with periodontitis and RA (PERIO+RA).

The impact of periodontitis and periodontal treatment on rheumatoid arthritis outcomes: an exploratory clinical trial.

Objective: Studies suggest rheumatoid arthritis (RA) patients could benefit from periodontal treatment. However, published data are inconsistent, and there is a need for better-controlled research. Our study aims to address these limitations.

Transcription Attenuation in Synthetic Promoters in Nonoverlapping Tandem Formation.

Closely spaced promoters are ubiquitous in prokaryotic and eukaryotic genomes. How their structure and dynamics relate remains unclear, particularly for tandem formations. To study their transcriptional interference, we engineered two pairs and one trio of synthetic promoters in nonoverlapping, tandem formation, in single-copy plasmids transformed into cells.

Molecular and spatial evaluation of small rodents and Didelphimorphis infected with Mycobacterium leprae in the southern Amazon, Brazil.

Background: The high levels of recent transmission of leprosy worldwide demonstrate the necessity of epidemiologic surveillance to understand and control its dissemination. Brazil remains the second in number of cases around the world, indicating active transmission of Mycobacterium leprae (M. leprae) in the population.

Analysis of peak locomotor demands in women's football-the influence of different epoch lengths.

The quantification of peak locomotor demands has been gathering researchers' attention in the past years. Regardless of the different methodological approaches used, the most selected epochs are between 1-, 3-, 5- and 15-minutes time windows. However, the selection of these time frames is frequently arbitrary.

Evaluation of data collection bias of third molar stages of mineralisation for age estimation in the living.

Age assessment of the living is a fundamental procedure in the process of human identification, in order to guarantee fair treatment of individuals, which has ethical, civil, legal, and medical repercussions. The careful selection of the appropriate methods requires evaluation of several parameters: accuracy, precision of the method, as well as its reproducibility. The approach proposed by Mincer et al adapted from Demirjian et al exploring third molar mineralisation, is one of the most frequently considered for age estimation of the living.

A library of reporters of the global regulators of gene expression in .

The topology of the transcription factor network (TFN) of is far from uniform, with 22 global regulator (GR) proteins controlling one-third of all genes. So far, their production rates cannot be tracked by comparable fluorescent proteins. We developed a library of fluorescent reporters for 16 GRs for this purpose.

An analysis of training load in highly trained female football players.

Unlabelled: This observational study aimed to analyze external training load in highly trained female football players, comparing starters and non-starters across various cycle lengths and training days.

Method: External training load [duration, total distance [TD], high-speed running distance [HSRD], sprint distance [SpD], and acceleration- and deceleration distance [AccDecdist] from 100 female football players (22.3 ± 3.

The Effect of Geoclimatic Factors on the Distribution of Paracoccidioidomycosis in Mato Grosso do Sul, Brazil.

The incidence of paracoccidioidomycosis (PCM) varies in Latin America, and it is influenced by environmental factors. This study evaluated the distribution of PCM acute/subacute form (AF) cases and their correlation with geoclimatic factors in the Mato Grosso do Sul (MS) state. The study included 81 patients diagnosed with the PCM/AF at the University Hospital of the Federal University of Mato Grosso do Sul between January 1980 and February 2022.

Parkin is a critical player in the effects of caffeine over mitochondrial quality control pathways during skeletal muscle regeneration in mice.

Aim: This study aimed to investigate the effects of caffeine on pathways associated with mitochondrial quality control and mitochondrial capacity during skeletal muscle regeneration, focusing on the role of Parkin, a key protein involved in mitophagy.

Methods: We used in vitro C2C12 myoblast during differentiation with and without caffeine in the medium, and we evaluated several markers of mitochondrial quality control pathways and myotube growth. In vivo experiments, we used C57BL/6J (WT) and Parkin 1Shn lineage (Parkin ) mice and injured tibial anterior muscle.

All that glitters is not gold: X-ray fluorescence analysis of a fixed dental prosthesis from Colecção de Esqueletos Identificados Século XXI, Portugal (CEI/XXI).

Access to better health care anticipates that more medical devices can be found alongside skeletal remains. Those employed in oral rehabilitation, with available brands or batch/series, can prove useful in the identification process. A previous study in the Colecção de Esqueletos Identificados Século XXI described macroscopically the dental prostheses.

Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil.

Background: Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006.

Methods: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state.