Publications by authors named "Bappanaidu Hoigegudde Krishnamurthy Rao"
A Phase 3, Double-Blind, Randomized Study of Arterolane Maleate-Piperaquine Phosphate vs Artemether-Lumefantrine for Falciparum Malaria in Adolescent and Adult Patients in Asia and Africa.
Offianan Andre Toure Neena Valecha Antoinette K Tshefu Ricardo Thompson Srivicha Krudsood Bappanaidu Hoigegudde Krishnamurthy Rao Ballamudi Srinivas Rao Deepak Rao
Clin Infect Dis
April 2016
Article Synopsis
- Artemisinins are at risk of supply disruptions due to climate change, leading to the development of a new synthetic antimalarial combination known as arterolane maleate (AM) with piperaquine phosphate (PQP) for treating uncomplicated malaria.
- In a clinical trial with 1072 patients, AM-PQP was found to have a high efficacy rate, with 90.48% showing adequate clinical and parasitological response at day 42, comparable to artemether-lumefantrine (A-L) which had a similar success rate.
- The study concluded that AM-PQP is as effective and safe as A-L in treating uncomplicated P. falciparum malaria, demonstrating quick parasite clearance and minimal