Novel case of combination antibiotic therapy for treatment of a complicated polymicrobial urinary tract infection with one organism harboring a metallo-β-lactamase (MBL) in a pregnant patient.

Carbapenem resistance due to metallo-beta-lactamases (MBLs) is a global phenomenon and an important challenge for antibiotic therapy (Boyd et al., 2020 [1]). While previous reports have demonstrated both and synergy using the combination of ceftazidime-avibactam and aztreonam against , an MBL-harboring organism, this treatment strategy has not been reported during pregnancy (Mojic et al.

An imaging review of the hippocampus and its common pathologies.

The hippocampus is a complex structure located in the mesial temporal lobe that plays a critical role in cognitive and memory-related processes. The hippocampal formation consists of the dentate gyrus, hippocampus proper, and subiculum, and its importance in the neural circuitry makes it a key anatomic structure to evaluate in neuroimaging studies. Advancements in imaging techniques now allow detailed assessment of hippocampus internal architecture and signal features that has improved identification and characterization of hippocampal abnormalities.

Electronic health record "gag clauses" and the prevalence of screenshots in peer-reviewed literature.

Objective: To determine whether the Office of the National Coordinator's policy change restricting the use of "gag clauses" in contracts between electronic health record (EHR) vendors and healthcare facilities increased the prevalence of screenshots in peer-reviewed literature.

Materials And Methods: We reviewed EHR usability and safety-related peer-reviewed journal articles from 2015 to 2023 and quantified the number of articles containing screenshots. For those that did not contain screenshots, we identified whether they would have benefited from screenshots.

A case of associated native valve endocarditis.

is rarely reported as a cause of endocarditis in immunocompetent patients. We describe a case of associated native valve endocarditis that was identified using matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) technology. While most species are generally resistant to vancomycin, is frequently susceptible, but treatment requires accurate susceptibility results followed by timely medical and surgical intervention.

Bipolar Electric-Field Switching of Perpendicular Magnetic Tunnel Junctions through Voltage-Controlled Exchange Coupling.

Perpendicular magnetic tunnel junctions (p-MTJs) switched utilizing bipolar electric fields have extensive applications in energy-efficient memory and logic devices. Voltage-controlled magnetic anisotropy linearly lowers the energy barrier of the ferromagnetic layer via the electric field effect and efficiently switches p-MTJs only with a unipolar behavior. Here, we demonstrate a bipolar electric field effect switching of 100 nm p-MTJs with a synthetic antiferromagnetic free layer through voltage-controlled exchange coupling (VCEC).

Eye and ocular adnexa manifestations of -related disorders.

Background: -related disorders are a rare group of intellectual disability syndromes with a broad range of phenotypic characteristics. The phenotypic spectrum of -related disorders currently includes X-Linked Ohdo Syndrome, Lujan-Fryns Syndrome (LS), and FG syndrome type 1 (FG), also known as Opitz-Kaveggia Syndrome. The gene encodes the largest component of the mediator complex of RNA polymerase II, which is critical for recruiting activators and repressors to regulate the transcription of genes critical to growth, development, and differentiation.

A 58-Year-Old Man with a Painful Gluteal Mass as the First Presentation of Metastatic Adenocarcinoma of the Lung.

BACKGROUND Lung cancer is the second most common cancer, with the highest mortality rate. It frequently metastasizes to the nervous system, bone, adrenal gland, and liver. Rarely, it metastasizes to soft tissues, including cutaneous, subcutaneous, and skeletal muscles, with an overall prevalence rate of 2.

A Case of Post-COVID-19 Subacute Thyroiditis.

Subacute thyroiditis is usually a self-limiting inflammatory condition. The clinical presentation varies from person to person, but usually includes neck pain or discomfort and a painful diffuse goiter. There is at times a transient episode of hyperthyroidism followed by euthyroidism and sometimes hypothyroidism.

Hemorrhagic Pericardial Effusion Leading to Cardiac Tamponade: A Rare Initial Presentation of Adenocarcinoma of the Lung.

Malignancy associated pericardial effusion is a serious condition and testifies to poor prognosis. Cardiac tamponade can be the first presentation of underlying adenocarcinoma of the lung. We present a 78-year-old female with no known history of any malignancy, who presented with symptoms of abdominal and respiratory pathology.

Tracking the Verwey Transition in Single Magnetite Nanocrystals by Variable-Temperature Scanning Tunneling Microscopy.

Variable-temperature scanning tunneling spectroscopy revealed a sharp Verwey transition in individual ∼10 nm magnetite nanocrystals prepared by the coprecipitation technique and embedded in the surface of a gold film. The transition was observed as a significant change in the electronic structure around the Fermi level, with an apparent band gap of ∼140-250 meV appearing below the transition temperature and a pseudogap of ∼75 ± 10 meV appearing above it. The transition temperature was invariably observed around 101 ± 2 K for different nanocrystals, as opposed to 123 K typically reported for stoichiometric bulk crystals.

Patterning of sub-50 nm perpendicular CoFeB/MgO-based magnetic tunnel junctions.

Perpendicular magnetic tunnel junctions (p-MTJs) were patterned into nanopillars using electron-beam lithography to study their scaling and switching behaviour. Magnetoresistance measurements of annealed and unannealed p-MTJ films using scanning probe microscopy showed good agreement with Monte Carlo modeling. p-MTJ pillars demonstrated clear parallel magnetic states, both 'up' or both 'down' following AC-demagnetization.

The ambidextrous cyclooxygenase: an enduring target.

With the discovery of COX, pain has not been treated in a relentless manner. Numbers of drugs with fewer side effects were discovered and are used successfully for treatment of pain. With new research coming into being since the discovery of COX, it was established that COX can be targeted not only for treatment of pain but for curing various diseases like cancer, Alzheimer's, Parkinson's disease, Glaucoma etc.

To identify morbidity and mortality predictors in acute organophosphate poisoning.

Background: Organophosphorus poisoning remains an important cause of morbidity and mortality, but no definite parameters have been identified as predictors of outcome. Prediction of morbidity at presentation might help in decision making in places of limited resources like rural settings in developing countries.

Materials And Methods: A total of 76 cases were included in this retrospective cohort study.

Ultrafast light induced unusually broad transient absorption in the sub-bandgap region of GeSe2 thin film.

In this paper, we show for the first time that ultrafast light illumination can induce an unusually broad transient optical absorption (TA), spanning of ≈ 200 nm in the sub-bandgap region of chalcogenide GeSe2 thin films, which we interpret as being a manifestation of creation and annihilation of light induced defects. Further, TA in ultrashort time scales show a maximum at longer wavelength, however blue shifts as time evolves, which provides the first direct evidence of the multiple decay mechanisms of these defects. Detailed global analysis of the kinetic data clearly demonstrates that two and three decay constants are required to quantitatively model the experimental data at ps and ns respectively.

Crossover from photodarkening to photobleaching in a-Ge(x)Se(100-x) thin films.

In this Letter, we present the interesting results of photodarkening (PD), transition toward photostability, and a slow crossover from PD to photobleaching when composition of the chalcogenide glassy thin film changes from Ge-deficient to rich. A subsequent Raman analysis on these as-prepared and irradiated samples provide the direct evidence of photoinduced structural rearrangement, i.e.

Airborne black carbon concentrations over an urban region in western India-temporal variability, effects of meteorology, and source regions.

This study characterizes over 5 years of high time resolution (5 min), airborne black carbon (BC) concentrations (July 2003 to December 2008) measured over Ahmedabad, an urban region in western India. The data were used to obtain different time averages of BC concentrations, and these averages were then used to assess the diurnal, seasonal, and annual variability of BC over the study region. Assessment of diurnal variations revealed a strong association between BC concentrations and vehicular traffic.

Static and cyclic loading of fiber-reinforced dental resin.

Objective: The aim of this study was to evaluate the flexure strength of unidirectional fiber-reinforced resins under static and cyclic loading with and without thermal cycling.

Methods: The fiber-reinforced resin materials chosen for this project were commercially available endodontic posts and commercially procured bar samples. For all materials, controls for flexure strength were tested in air and in water using three-point loading.

Vitamin E improves bone quality in the aged but not in young adult male mice.

It is generally viewed that with advancing age, humans and other animals including mice experience a gradual decline in the rate of bone formation. This, in part, may be due to the rise in oxygen-derived free radical formation. Vitamin E, a strong antioxidant, functions as a free radical scavenger that potentially can suppress bone resorption while stimulating bone formation.

Effects of aging and cyclic loading on the mechanical properties of glass ionomer cements.

The purpose of this study was to examine the effect of cyclic loading on the flexural strength and fracture toughness of a conventional glass ionomer cement (GIC), a metal containing GIC, hybrid GICs, and, for comparison, a composite. Two sets of specimens were evaluated: a set of controls (at 37 degrees C and 95% humidity) and a set aged for 9 months at 37 degrees C in water. The specimens were tested in static loading in air and water, and cyclic loaded in water.

Mechanical property evaluation of pressable restorative ceramics.

Objective: The aim of this study was to evaluate the flexure strength under static and cyclic loading and the fracture toughness under static loading of six restorative ceramic materials. Specifically the intent was to compare four leucite (K2O.Al2O(3).

Relative solubilities of hybrid ionomers and compomers by acid impingement.

The purpose of this investigation was to determine the relative erosion/solubility for hybrid glass-ionomers and a compomer using the jet-impingement technique with lactic acid of various molarities. The materials studied included Dyract, Duet, Vitremer, Advance, Fuji-II LC, and Fuji-I, Ketac Cem and Modern Tenacin as the control. Data were analysed using ANOVA and Tukey's comparison test.

Study of devitrification of Dicor glass.

The nucleation and crystallization of tetrasilicic fluormica crystals in the Dicor group of glass ceramics is not as well understood as the crystallization sequence of trisilicic mica in the Macor group of glass ceramics. The main aim of this investigation was to obtain kinetic data of crystallization and to examine the devitrification process at different stages of heat treatment during non-isothermal heating. The kinetic parameters, such as the activation energy, Ec, the reaction order, n, and the frequency factor, v, for the devitrification reaction were computed using the Johnson-Mehl-Avrami (JMA) equation and the data from differential thermal analysis (DTA).