Rhoifolin Alleviates Alcoholic Liver Disease and Inhibition of the TLR4/NF-κB Signaling Pathway.

Alcoholic liver disease (ALD) is a common chronic liver disorder worldwide, which is detrimental to human health. A preliminary study showed that the total flavonoids within "Tomentosa" exerted a remarkable effect on the treatment of experimental ALD. However, the active substances of "Tomentosa" were not elucidated.

Rhoifolin Alleviates Inflammation of Acute Inflammation Animal Models and LPS-Induced RAW264.7 Cells via IKKβ/NF-κB Signaling Pathway.

Rhoifolin (ROF) is a main effective component in Citrus grandis 'Tomentosa'. ROF has a potential anti-inflammatory activity, but its specific effects and mechanisms have not been studied. This study investigated the anti-inflammatory activity of ROF and searched for its possible molecular mechanisms.