Robust and flexible polyester fiber membrane with under-liquid dual superlyophobicity for efficient on-demand oil-water separation.

Functional materials with under-liquid dual superlyophobicity have generated a great deal of concern from researchers due to their switchable separation ability oil-water mixtures and emulsions. Conceptually, under-liquid dual superlyophobicity is a Cassie state achievable under-liquid through the synergy of an under-liquid double lyophobic surface and the construction of a highly rough surface. However, obtaining an under-liquid dual superlyophobic surface remains difficult due to its thermodynamic contradiction and complex surface composition.

Diversity in Fruit Morphology and Nutritional Composition of Maxim in Northeast China.

Although Manchurian walnut ( Maxim) is widely distributed in northeast China, very few studies had been reported on its diversity among different populations. We surveyed 12 populations in their native habitats across the northeast region of China and profiled 13 fruit morphological traits. We found a large degree of variations for these traits, especially for fruit weight (coefficient of variation, or CV of 22.

Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C-Lock linker.

Antibody-drug conjugates (ADCs) belong to a promising class of biopharmaceuticals in which target-killing of tumor cells was achieved by marrying the potency of the cytotoxic payload with the tumor specificity of the antibody. Here we developed a novel ADC (ZV0508) that targets 5T4 oncofetal antigen, which is overexpressed in many carcinomas on both bulk tumor cells and cancer stem cells. A novel cytotoxic payload called Duostatin-5 (Duo-5) which was derived from monomethyl auristatin F (MMAF) was attached to a 5T4 targeting antibody (ZV05) by interchain cysteine cross-linking conjugation via a disubstituted C-Lock linker.