Visible-Light-Promoted Synthesis of α-CFH-Substituted Ketones by Radical Difluoromethylation of Enol Acetates.

An efficient and novel visible-light-promoted radical difluoromethylation of enol acetates for the synthesis of α-CFH-substituted ketones has been described. Upon irradiation under blue LED with catalytic amounts of -Ir(ppy), this photocatalytic procedure employs difluoromethyltriphenylphosphonium bromide as a radical precursor. Various α-CFH-substituted ketones are successfully created via designed systems based on the SET process.