Synopsis of recent research by authors named "Baoxiang Guan"
- Baoxiang Guan's research primarily focuses on understanding the tumor microenvironment's role in cancer progression and treatment resistance, particularly in cancers such as pancreatic and urothelial carcinoma, highlighting the influence of immune checkpoint therapy and associated biomarkers.
- His studies reveal mechanisms behind immune checkpoint therapy resistance, identifying factors such as TSG-6 expression in pancreatic tumors and the impact of tumor immunogenicity on therapy response, indicating the need for personalized treatment approaches based on tumor and immune microenvironment characteristics.
- Guan also investigates therapeutic strategies such as combination therapies to enhance the efficacy of immune treatments, demonstrating that blockade of CTLA-4 and PD-1 synergistically improves anti-tumor responses and suggesting potential biomarkers for patient selection in immunotherapy.
