Publications by authors named "Baowei Jing"
Article Synopsis
- Researchers developed a dual-CRISPR RNA library method for effective combinational genetic screening, aimed at identifying genetic interactions.
- The method utilizes CeCas12a, which offers precise PAM recognition and minimal off-target effects, enhancing the accuracy of the screening process.
- By targeting kinase and metabolism-associated genes related to FDA-approved drugs linked to liver cancer, this approach identifies potential genetic interactions that could lead to new cancer treatments.
Evidence shows that some class I human leucocyte antigen (HLA) alleles are related to durable HIV controls. The T18A TCR, which has the alloreactivity between HLA-B∗42:01 and HLA-B∗81:01 and the cross-reactivity with different antigen mutants, can sustain long-term HIV controls. Here the structural basis of the T18A TCR binding to the immunodominant HIV epitope TL9 (TPQDLNTML180-188) presented by HLA-B∗42:01 was determined and compared to T18A TCR binding to the TL9 presented by the allo-HLA-B∗81:01.
View Article and Find Full Text PDFMetabolic competition between tumors and T cells is fierce in the tumor microenvironment (TME). Tumors usually exhaust glucose and accumulate lactic acid in TME. Nutrient deprivation and lactic acid accumulation in TME blunt T cell functions and antitumor immune responses.
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