Publications by authors named "Baoshuo Qian"
Free Radic Biol Med
February 2025
Article Synopsis
- Modulating the balance between glucose and fatty acid metabolism is a promising therapy for myocardial ischemia/reperfusion (I/R) injury, with Sphingosylphosphorylcholine (SPC) showing cardioprotective effects during heart attacks by influencing various transcription factors.*
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- The study found that knocking out the GATA zinc finger domain protein 1 (GATAD1) in heart tissue led to increased heart damage and reduced the protective impact of SPC in I/R mice, indicating GATAD1's role in cardiac health.*
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- GATAD1 regulates the expression of genes related to fatty acid oxidation and glucose oxidation, suggesting that SPC might prevent I/R injury by shifting metabolism in favor
