Publications by authors named "Baoshuai Xue"
H-NS is a prokaryotic histone-like protein that binds to bacterial chromosomal DNA with important regulatory roles in gene expression. Unlike histone proteins, hitherto post-translational modifications of H-NS are still largely uncharacterized, especially in bacterial pathogens. Salmonella Typhimurium is a primary enteric pathogen and its virulence is mainly dependent on specialized type III secretion systems (T3SSs), which were evolutionarily acquired via horizontal gene transfer.
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- V. cholerae develops complex mechanisms to handle host stress, leading to the emergence of nonmotile mutants that enhance its colonization in mice.
- Mutations primarily occur in flagellar regulator genes like flrA, flrC, and rpoN, rather than in traditional genes related to DNA repair or scavenging systems.
- The cyclin gene dps plays a crucial role, with its deletion resulting in a significant increase in mutation rates, suggesting it influences the formation of nonmotile mutants as a strategy for better adaptation in the host environment.
is one of the most important food-borne pathogens, whose motility and virulence are highly related to flagella. Flagella alternatively express two kinds of surface antigen flagellin, FliC and FljB, in a phenomenon known as flagellar phase variation. The molecular mechanisms by which the switching orientation of the Hin-composed DNA segment mediates the expression of the promoter have been thoroughly illustrated.
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