Potential of ultrasound stimulation and sonogenetics in vision restoration: a narrative review.

Vision restoration presents a considerable challenge in the realm of regenerative medicine, while recent progress in ultrasound stimulation has displayed potential as a non-invasive therapeutic approach. This narrative review offers a comprehensive overview of current research on ultrasound-stimulated neuromodulation, emphasizing its potential as a treatment modality for various nerve injuries. By examining of the efficacy of different types of ultrasound stimulation in modulating peripheral and optic nerves, we can delve into their underlying molecular mechanisms.

High-frequency wearable ultrasound array belt for small animal echocardiography.

Wearable ultrasound has been widely developed for long-term, continuous imaging without the need for bulky system manipulation and repeated manual locating. To potentially lead to more accurate and reliable imaging monitoring, this work presents the design, fabrication, and evaluation of a novel high-frequency wearable ultrasound array belt (WUAB) for small animal echocardiography. The fabrication process involved precise dicing technology for a λ-pitch design.

Photostable yellow emissive carbon dots for iron-mediated reversible sensing of biothiols and cellular imaging.

The different levels of biothiols in cells can not only screen cancer cells but also play a selective role in killing cancer cells. Therefore, accurate monitoring of biothiol in cancer cells is of great research significance. Herein, novel yellow emission CDs (Y-CDs) were prepared by a simple hydrothermal method using 2, 5-dihydroxyterephthalic acid (DHTA) as precursors.

Synergistic Effect of Nano-Silica and Intumescent Flame Retardant on the Fire Reaction Properties of Polypropylene Composites.

Silica nanoparticles (nano-silica) were used as synergistic agents with ammonium polyphosphate (APP) and pentaerythritol (PER) to enhance flame retardancy of polypropylene (PP) in this research. The composites were prepared using a melt-mixing method. The influences of nano-silica on the fire performance of composites were thoroughly discussed, which promotes understanding of nano-silica on the flame-retardant performance of polypropylene composite.

A Novel Dual-Element Catheter for Improving Non-Uniform Rotational Distortion in Intravascular Ultrasound.

For the early diagnosis of atherosclerosis and interventions, intravascular ultrasound (IVUS) is a valuable tool for intravascular luminal imaging. Compared with the array-based method, mechanically rotating IVUS catheters dominate the clinical applications because of their less complexity and better suitability for high-frequency ultrasound imaging. However, mechanically rotating catheters are suffering from non-uniform rotational distortion (NURD) which hinders accurate image acquisition.

Gadolinium (III) doped carbon dots as dual-mode sensor for the recognition of dopamine hydrochloride and glutamate enantiomers with logic gate operation.

Dopamine hydrochloride (DH) and D-Glutamic acid (D-Glu) are important excitatory neurotransmitters, which are closely relative to central nervous system diseases. Therefore, it is critical to develop the sensitive and facile sensor to precisely monitor the changes of these neurotransmitters. Herein, the gadolinium-doped carbon dots (Gd-CDs) were synthesized by a low-cost and effortless one-pot solvothermal method.

Surface state dominated and carbon core coordinated red-emitting carbon dots for the detection of CrO and cell imaging.

Cr(VI) as a toxic heavy metal ion can easily enter into the body through drinking or eating and cause liver and kidney diseases as well as cancer. Considering its high biological toxicity and adverse effects on human body, it is desirable to develop a probe to monitor its level in the environment. Herein, a high-efficiency fluorescent nanoprobe based on red emissive carbon dots (R-CDs) was established through a convenient solvothermal strategy.

Dual-responsive nano-prodrug micelles for MRI-guided tumor PDT and immune synergistic therapy.

Micelles as nanocarriers not only offer new opportunities for early diagnosis and treatment of malignant cancers but also encounter numerous barriers in the path of efficient delivery of drugs to diseased areas in the body. To address these issues, we developed a pH/GSH responsive nano-prodrug micelle (NLG919/PGA-Cys-PPA@Gd) with a high drug-loading ratio and controlled drug release performance for MRI-guided tumor photodynamic therapy (PDT) and immune synergistic therapy. Under normal conditions, theranostic nanomicelles remained stable and in a photo-quenched state.

Nitrogen-doped carbon dots as a fluorescent probe for folic acid detection and live cell imaging.

The folic acid (FA) level in human body can be used as an indicator for body's normal physiological activities and offer insight into the growth and reproduction of the body's cells. But the abnormal level of FA can cause some diseases. Herein, we designed a simple and convenient approach to prepare fluorescent N-doped carbon dots (N-CDs) for the FA detection.

Evaluation of Blood Induced Influence for High-Definition Intravascular Ultrasound (HD-IVUS).

High-definition intravascular ultrasound (HD-IVUS) utilizing more than 80 MHz frequency to assess atherosclerotic plaque, can theoretically achieve an axial resolution of less than [Formula: see text]. However, the blood is a high-attenuation source at high frequency, which would affect the imaging quality. There has been no research evaluating the blood-induced influence on HD-IVUS imaging.

A novel dual-frequency imaging method for intravascular ultrasound applications.

Intravascular ultrasound (IVUS), which is able to delineate internal structures of vessel wall with fine spatial resolution, has greatly enriched the knowledge of coronary atherosclerosis. A novel dual-frequency imaging method is proposed in this paper for intravascular imaging applications. A probe combined two ultrasonic transducer elements with different center frequencies (36 MHz and 78 MHz) is designed and fabricated with PMN-PT single crystal material.

Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives.

A series of 5-phenyliminobenzo[a]phenoxazine derivatives were synthesized. The in vitro antiprotozoal activities were evaluated against Plasmodium falciparum K1, Trypanosoma cruzi, Leishmania donovani and Trypanosoma brucei rhodesiense. N,N-Diethyl-5-((4-methoxyphenyl)imino)-5H-benzo[a]phenoxazin-9-amine shows IC(50)=0.

Fabrication of ionic liquid-functionalized polypyrrole nanotubes decorated with platinum nanoparticles and their electrocatalytic oxidation of methanol.

Polypyrrole nanotubes (PPyNTs)/Pt nanoparticle hybrids were synthesized by using covalently attached imidazolium-type ionic liquids (ILs) as linkers. The resultant Pt/ILs/PPyNTs hybrids exhibited high electrocatalytic activity in electrocatalytic oxidation of methanol.