Publications by authors named "Baoning Zhang"
An "AND"-logic-gate-based fluorescent probe NAP-DCP-4 with dual reactive sites is reported, which has improved selectivity for methylglyoxal over glyoxal, featuring formaldehyde-enhanced methylglyoxal detection and irreversible and reversible turn-on fluorescence responses at different excitation wavelengths. Its cell-impermeability enables facile monitoring of extracellular methylglyoxal level changes in the supernatant of activated macrophages.
View Article and Find Full Text PDFBackground: The concordance rate of human epidermal growth factor receptor 2 (HER2) status between core needle biopsy (CNB) and subsequent excisional biopsies of the same tumor varies from 81 to 96%, which may cause inappropriate neoadjuvant therapy that impair the potential benefit from HER2 targeted therapy for patients. This study aimed to establish a nomogram to predict the HER2 status pre-operatively as an auxiliary diagnosis to CNB assessment.
Methods: Among 4211 breast cancer patients cataloged in the Nation-wide Multicenter 10-year Retrospective Clinical Epidemiological Study of Breast Cancer in China, 2291 patients with complete relevant information were included in this study, which were further randomized 3:1 and divided into a training set and a validation set.
Article Synopsis
- The study analyzed the medical records of 4,211 female breast cancer patients in China to assess the influence of occupation and education on cancer staging, treatment choices, and clinical features.
- Both occupation and education were found to be independent factors affecting the timing of diagnosis and treatment implementation, with lower-income and lower-educated groups facing later-stage tumors and fewer treatment options.
- The findings indicate a need for targeted strategies to improve breast cancer prevention and care for women with lower educational backgrounds and specific occupations.
Article Synopsis
- The study aimed to create a predictive model for axillary lymph node metastasis in breast cancer patients to inform surgical decisions, reducing unnecessary procedures.
- The analysis involved 4211 female breast cancer patients from seven centers in China, using various clinical factors to identify independent predictors of metastasis for the model.
- The developed nomogram demonstrated strong predictive capabilities, suggesting that if the predicted risk is under 20%, sentinel lymph node biopsy might not be necessary, potentially leading to less invasive surgical options in the future.
Purpose: In premenopausal women with metastatic hormone receptor-positive breast cancer, hormonal therapy is the first-line therapy. Gonadotropin-releasing hormone analogue + tamoxifen therapies have been found to be more effective. The pattern of recurrence risk over time after primary surgery suggests that peri-operative factors impact recurrence.
View Article and Find Full Text PDFBackground: The study aimed to describe the age distribution of breast cancer diagnosis among Chinese females for comparison with the United States and the European Union, and provide evidence for the screening target population in China.
Materials And Methods: Median age was estimated from hospital databases from 7 tertiary hospitals in China. Population-based data in China, United States and European Union was extracted from the National Central Cancer Registry, SEER program and GLOBOCAN 2008, respectively.
Article Synopsis
- The study investigates the use and trends of intraoperative frozen section examination (IFSE) during breast cancer surgeries among 4,211 patients in China from 1999 to 2008.
- Results show that over half (54.22%) of patients underwent IFSE, with increased use linked to more sentinel lymph node biopsies and breast-conserving surgeries, exhibiting significant regional variations.
- The research highlights the need for tailored patient education and screening programs, and suggests policymakers should address treatment disparities linked to socioeconomic factors in order to improve breast cancer management in China and similar low-income countries.
Article Synopsis
- The study aimed to assess how well breast cancer patients in China complied with postmastectomy radiation therapy (PMRT) guidelines over a 10-year span.
- Researchers analyzed data from 2310 patients across seven hospitals, categorizing them into three groups based on National Comprehensive Cancer Network guidelines and tracking PMRT utilization.
- Findings showed that PMRT usage increased in the recommended and controversial groups over the years, while remaining low in the nonrecommended group, indicating a need for improved adherence to treatment guidelines among certain patient populations.
Article Synopsis
- The study examines the link between body mass index (BMI) and breast cancer receptor status (ER/PR/HER2) in Chinese women, focusing on both pre- and post-menopausal groups.
- A total of 4,211 breast cancer patients were analyzed, with statistical methods used to assess whether BMI varied with biological receptor status, especially in post-menopausal women.
- Findings indicate that post-menopausal women with a BMI of 24 kg/m² or higher had a significantly higher prevalence of PR+ breast cancer, suggesting that high BMI may influence breast cancer risk through mechanisms beyond estrogen metabolism.
Article Synopsis
- The study examines the variations in breast cancer risk factors across different regions and demographics, highlighting the importance of local characteristics for prevention strategies.
- The research analyzed data from 4,211 women with breast cancer, comparing factors like childbirth, breastfeeding, and weight among different regions, menopausal statuses, and birth periods.
- Key findings indicated that women in more developed regions were less likely to have children and breastfeed, while postmenopausal women showed a stronger association with being overweight and having more childbirths, stressing the need to focus on these risk factors for effective breast cancer risk assessments in Chinese women.
Article Synopsis
- The study examined invasive breast cancer characteristics based on molecular subtypes, recruiting patients with detailed receptor expression data.
- Findings revealed that luminal A was the most common subtype, followed by triple-negative, with significant differences in tumor size, stage, and lymph node status among subtypes.
- The results suggest that variations in molecular subtypes by age and region may inform updates to treatment guidelines and personalized treatment approaches in China.
Purpose: To study the change of surgical treatments for breast cancer in China over the recent 10 years and the relationship between such a changes and social economical development.
Methods: The data were extracted from the 10-year database of female primary breast cancer at 7 tertiary hospitals from various geographic areas in China. The Chi-square Cochran-Armitage trend test was used to measure the difference.
A feasibility study of the intraductal administration of chemotherapy.
Cancer Prev Res (Phila)
January 2013
Preclinical data have shown the potential of the intraductal administration of chemotherapy for breast cancer prevention. Direct translation of this work has been stymied by the anatomical differences between rodents (one duct per teat) and women (5-9 ductal systems per breast). The objective of this phase I study was to show the safety and feasibility of intraductal administration of chemotherapy drugs into multiple ducts within one breast in women awaiting mastectomy for treatment of invasive cancer.
View Article and Find Full Text PDF[10-year changes and development of surgical treatment for breast cancer in China].
Zhonghua Zhong Liu Za Zhi
August 2012
Objective: To investigate the changes and development of surgical treatment for breast cancer from 1999 to 2008 in China, and compare the differences between the surgical methods used in high-resource and low-resource areas.
Methods: Clinicopathological data of surgical treatment for female primary breast cancer was collected via medical chart review at hospitals in seven geographic areas in China. Chi-square test and chisqure test for linear trends were used to analyze the changes and development of the surgical methods used for breast cancer in the 10 years.
Background: To investigate the use of radiotherapy (RT) in China in patients with breast cancer over a 10-year period. A hospital-based, nationwide, multicenter, retrospective epidemiologic study of women with primary breast cancer was conducted.
Patients And Methods: Patients were selected randomly in 7 hospitals from 1999 to 2008.
Article Synopsis
- The study examined characteristics of mammary Paget's disease (PD) among breast cancer patients in China, analyzing data from 4211 cases across seven hospitals between 1999 and 2008.
- PD was found in 1.6% of breast cancer cases, mainly affecting premenopausal women with an average diagnosis age of 48.1; the typical presentation included a palpable breast mass and often accompanied undiagnosed invasive cancer.
- Patients with PD and invasive breast cancer exhibited larger tumors and more aggressive features, prompting the need for improved diagnostic and treatment protocols for mammary Paget's disease in the country.
Introduction: To screen the risk factors associated with breast cancer among Chinese women in order to evaluate the individual risk of developing breast cancer among women in China.
Material And Methods: A case-control study on 416 breast cancer patients and 1156 matched controls was conducted in 14 hospitals in 8 provinces of China in 2008. Controls were age- and region-matched to the cases.
Background: Although socioeconomic status (SES) has been focused on as a key determinant of cancer stage at diagosis in western countries, there has been no systemic study on the relationship of SES and breast cancer stage at diagnosis in China.
Methods: The medical charts of 4,211 eligible breast cancer patients from 7 areas across China who were diagnosed between 1999 and 2008 were reviewed. Four area-based socioeconomic indicators were used to calculate area-based SES by cluster analysis.
Background: According to the very limited cancer registry, incidence and mortality rates for female breast cancer in China are regarded to be increasing especially in the metropolitan areas. Representative data on the breast cancer profile of Chinese women and its time trend over years are relatively rare. The aims of the current study are to illustrate the breast cancer profile of Chinese women in time span and to explore the current treatment approaches to female breast cancer.
View Article and Find Full Text PDFBackground: Although chemotherapy is one of the most important treatments of breast cancer, it is limited by significant inter-individual variations in response and toxicity. The metabolism of epirubicin (EPI) and cyclophosphamide (CTX) is mainly mediated by cytochrome P450s (CYPs) and glutathione S-transferases (GSTs). It has been well-known that the activities of these enzymes are polymorphic in population due to their genetic polymorphisms.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates touch imprint cytology (TIC) for diagnosing breast cancer, highlighting its high sensitivity (96.2%) and accuracy (95.8%) compared to core needle biopsy (CNB).
- It shows TIC's false negative (1.4%) and false positive (0.35%) rates, confirming its reliability and effectiveness in detecting malignant cases.
- Additionally, the conformity rates for immunocytochemistry (ICC) and immunohistochemistry (IHC) are promising, suggesting TIC can reliably assess hormone receptor levels before neoadjuvant chemotherapy.
Article Synopsis
- The study classified breast cancer into four molecular subtypes based on immunohistochemical tests for ER, PR, and HER-2 and aimed to analyze their clinical features.
- Among 408 patients, the majority had the Luminal A subtype, while Basal-like subtype showed lower lymph node metastases, and HER-2 subtype had fewer younger patients.
- The results indicated that Luminal A had the highest 5-year overall survival rate (89.83%) and lower recurrence/metastasis rates compared to other subtypes, highlighting the need for individualized treatment approaches.
Article Synopsis
- The study aimed to compare the clinical characteristics and outcomes of triple-negative (TN) breast cancer patients with those of non-triple-negative (NTN) patients, analyzing data from 408 cases.
- TN patients were generally younger and had larger tumors but exhibited a higher rate of local recurrence and metastasis, particularly to the lungs, compared to NTN patients.
- The findings indicated that TN patients had significantly lower overall and disease-free survival rates, highlighting the need for tailored treatment strategies for those diagnosed with TN breast cancer.
[Clinicopathological characteristics and prognosis of patients with breast cancer over 65 years of age].
Zhonghua Yi Xue Za Zhi
January 2009
Objective: To study clinicopathological characteristics and prognosis of elderly women with breast cancer.
Methods: The data of 399 patients with breast cancer over 65 years of age was analyzed retrospectively in the Cancer Hospital of Chinese Academy of Medical Sciences from January 1989 to December 2003.
Results: Curative resection was performed for all patients, including modified radical mastectomy 277 (69.