[Three-dimensional finite element analysis of the influence of an abutment buffer layer on implant stress distribution].

Objective: To study the stress distribution under dynamic loading in the presence or absence of an abutment buffer layer by using three-dimensional finite element analysis.

Methods: A three-dimensional solid geometric model of an implant in a human mandible was established on the basis of CT scan data. A buffer-free abutment prosthesis and a buffer-abutment abutment prosthesis were installed above the implant.

Co-delivery of vincristine and quercetin by nanocarriers for lymphoma combination chemotherapy.

Purpose: Chemotherapy is the current standard treatment for Non-Hodgkin's lymphoma (NHL). Combination therapy is emerging as an important strategy for a better long-term prognosis with decreased side effects, maximized therapeutic effect. The aim of this study is to deliver vincristine (VCR) and quercetin (QU) with synergistic drug ratios through lipid-polymeric nanocarriers (LPNs) for the lymphoma combination chemotherapy METHODS: In this present study, we constructed VCR and QU dual-loaded LPNs (VCR/QU LPNs) and investigated their antitumor efficacy in vitro cell culture models and a tumor xenograft mouse model.

Novel transferrin modified and doxorubicin loaded Pluronic 85/lipid-polymeric nanoparticles for the treatment of leukemia: In vitro and in vivo therapeutic effect evaluation.

Purpose: Childhood leukemia is a common malignant disease in children. Doxorubicin (DOX) was widely used for the treatment of leukemia. However, severe toxic side effects and drug resistance are the major limitations of DOX.

[Effects of fluid shear stress time on carbonic anhydrase in rat osteoclasts].

Purpose: To observe the effects of fluid shear stress on carbonic anhydrase II in rat osteoclasts.

Methods: Osteoclasts were subject to fluid shear stress for 0,15,30,60 and 120 minutes respectively, which was 2.9dyne/cm(2).

[Effects of fluid shear stress strength on mRNA expression of ATP6V1a1 in polarized osteoclasts].

Objective: To observe effects of fluid shear stress strength on mRNA expression of ATP6V1a1 in rat polarized osteoclasts.

Methods: Rat polarized osteoclasts suffered 0.0 (control group), 0.

[3-Dimensional finite element analysis of single implant-supported prosthesis with three different occlusal designs].

This study was directed at analyzing the stress distribution of the implant in three different models whose cusp inclinations are 45, 35, 25 degrees respectively; the aim was to improve the success rate of implant rehabilitation. The method of is 3-dimensional finite element analysis (3D-FEA) was adopted. A volunteer's mandible was scanned using helix computer tomography and then we got the data of the mandible's margin in digital instrument.

[A biomechanical system that can apply fluid shear stress to osteoclast-like cells in vitro].

On the basis of the well-established principles and techniques about flow chamber, we have designed and made a kind of parallel plate system to apply steady fluid shear stress to osteoclast-like cells etc. in vitro. Biocompatible rubber and metal clamping apparatus made of aluminium alloy are used to seal the flow chamber without changing its even height designed beforehand.