Integrated Bioinformatics Analysis of DNA Methylation Biomarkers in Thyroid Cancer Based on TCGA Database.

Previous studies have reported a cluster of aberrant promoter methylation changes associated with silencing of tumor suppressor genes in thyroid cancer (TC), but these results of individual genes are far from enough. In this work, we aimed to investigate the onset and pattern of methylation changes during the progression of TC by informatics analysis. We downloaded the DNA methylation and RNA sequencing datasets from The Cancer Genome Atlas focusing on TC.

The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis.

Objective: Recent controversial evidence suggests that maternal diabetes may increase the risk of attention deficit and hyperactivity disorder (ADHD) in offspring. To examine this potential association, a systematic literature search and meta-analysis was performed.

Methods: OR or risk ratio (RR) from each study was obtained and combined for evaluating the risk.

Monocular-Vision-Based Autonomous Hovering for a Miniature Flying Ball.

This paper presents a method for detecting and controlling the autonomous hovering of a miniature flying ball (MFB) based on monocular vision. A camera is employed to estimate the three-dimensional position of the vehicle relative to the ground without auxiliary sensors, such as inertial measurement units (IMUs). An image of the ground captured by the camera mounted directly under the miniature flying ball is set as a reference.

[Features of vitreomacular traction syndrome assessed with three-dimensional spectral-domain optical coherence tomography].

Objective: To describe features of vitreomacular traction syndrome (VMT) on three-dimensional (3D) spectral-domain optical coherence tomography (SD OCT).

Methods: Eighteen eyes of 18 patients with VMT were diagnosed by SD OCT. SD OCT images were obtained and retrospectively analyzed.

Choroidal folds in acute Vogt-Koyanagi-Harada disease.

Purpose: To shed light on the clinical significance of choroidal folds (CFs) in acute Vogt-Koyanagi-Harada disease (VKH).

Methods: Twenty-three acute uveitic VKH patients diagnosed between October 2001 and January 2008 were reviewed retrospectively.

Results: Twelve (52%) patients had CFs; for patients with CFs, more had poor initial visual acuity ( View Article and Find Full Text PDF

[Clinical manifestation and follow-up of melanocytoma of the optic disc].

Objective: To investigate the clinical manifestation and follow-up of melanocytoma of the optic disc.

Methods: Retrospective case series study was taken to study the clinical data of the cases with melanocytoma of the optic disc at Peking Union Medical College Hospital from 1978 to 2007. The examination included direct and indirect ophthalmoscopy, fundus photography, fundus fluorescein angiography (FFA), fundus indocyanine green angiography (ICGA), optical coherence tomography (OCT) and B-scan.

[Follow-up and management of Coats disease diagnosed in childhood].

Objective: To investigate retrospectively the clinical manifestation and the final visual prognosis through a long-term fellow-up study.

Methods: It was retrospective case series study. Twenty four patients (26 eyes) were diagnosed with Coats disease from 1962 through 2006 at the Department of Ophthalmology, Peking Union Medical Hospital, Chinese Academy of Medical Sciences.

[Long-term follow-up and management of choroidal osteoma].

Objective: To report the clinical characteristics, long-term follow-up and management of choroidal osteoma.

Methods: Eighteen eyes of 12 cases (5 male and 7 female) of choroidal osteoma were studied. Best corrected vision, intraocular pressure, perimetry, anterior segment and eye fundus were examined routinely.

[Transpupillary thermotherapy for circumscribed choroidal hemangioma].

Objective: To evaluate the efficacy of transpupillary thermotherapy (TTT) on circumscribed choroidal hemangioma.

Methods: Ten eyes of 10 cases with circumscribed choroidal hemangioma (age 16-48, average 34.4) were included in the present study.

[Cytomegalovirus retinitis associated with Acquired immunodeficiency syndrome].

Objective: To investigate the fundus characteristics, systemic features and therapeutic outcomes of cytomegalovirus (CMV) retinitis associated with acquired immunodeficiency syndrome (AIDS).

Methods: Fundus features, visual acuity, fundus fluorescence angiography (FFA) and CD4(+)T-lymphocyte counts of 15 eyes (8 patients) of CMV retinitis associated with AIDS were analyzed. The time of average follow-up was 16 months.

[Krypton laser photocoagulation at low power setting for age-related macular degeneration complicated with subfoveal choroidal neovascularization].

Objective: To evaluate the efficacy of krypton laser photocoagulation for treatment of age-related macular degeneration (AMD) complicated with mainly subfoveal classic choroidal neovascularization (CNV).

Methods: Seventeen eyes of 17 cases, aged 50 - 74 years (averaged 60.8 years) with mainly subfoveal classic choroidal neovascularization were treated with krypton laser at lower power setting.

[Natural course and prognosis of visual acuity in patients of age-related macular degeneration with occult choroidal neovascularization].

Objective: To investigate the natural course and the final visual acuity in patients of age-related macular degeneration with choroidal neovascularization.

Methods: Thirty five eyes of 29 patients diagnosed as AMD with occult choroidal neovascularization were studied. The eyes which had laser, radiation therapy or surgical treatment were excluded.