GSNOR overexpression enhances CAR-T cell stemness and anti-tumor function by enforcing mitochondrial fitness.

Chimeric antigen receptor-T (CAR-T) cell has been developed as a promising agent for patients with refractory or relapsed lymphoma and leukemia, but not all the recipients could achieve a long-lasting remission. The limited capacity of in vivo expansion and memory differentiation post activation is one of the major reasons for suboptimal CAR-T therapeutic efficiency. Nitric oxide (NO) plays multifaceted roles in mitochondrial dynamics and T cell activation, but its function on CAR-T cell persistence and anti-tumor efficacy remains unknown.

Loss of Lkb1 in CD11c myeloid cells protects mice from diet-induced obesity while enhancing glucose intolerance and IL-17/IFN-γ imbalance.

Adipose tissue CD11c myeloid cell is an independent risk factor associated with obesity and metabolic disorders. However, the underlying molecular basis remains elusive. Here, we demonstrated that liver kinase B1 (Lkb1), a key bioenergetic sensor, is involved in CD11c cell-mediated immune responses in diet-induced obesity.

spp. as functional foods: A review of current status, challenges, and strategies.

Members of are among the first microbes to colonize the human intestine naturally, their abundance and diversity in the colon are closely related to host health. Recently, the gut microbiota has been gradually proven to be crucial mediators of various metabolic processes between the external environment and the host. Therefore, the health-promoting benefits of spp.

Deciphering the Heterogeneity of Mitochondrial Functions During Hematopoietic Lineage Differentiation.

Background: The heterogeneity of mitochondrial function is an important feature of hematopoietic cell lineage differentiation, but its stage wise contribution is not adequately studied. To establish a model to compare the lineage differentiation of hematopoietic stem cells (HSCs), hematopoietic progenitor cells (HPCs), and differentiated blood cells, the mitochondrial mass (MM), mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and mitophagy level were analyzed.

Results And Discussion: HSCs had lower mitochondrial metabolic activity than committed progenitor populations, indicated by lower MM, MMP, and ROS and higher mitophagy.

The Analysis of How Apnea Influences the Autonomic Nervous System Using Short-Term Heart Rate Variability Indices.

Objective: Frequent cessations of respiration can greatly increase the prevalence rate of arrhythmia. It has been confirmed that cardiac modulation is regulated by the autonomic nervous system (ANS). And heart rate variability (HRV) is widely used as a method to evaluate the function of the ANS.

Structural characterization and immunological activity of pectin polysaccharide from kiwano (Cucumis metuliferus) peels.

Two novel polysaccharides, namely CMPP-1 and CMPP-2, from kiwano (Cucumis metuliferus) peels were isolated through hot-water extraction, followed by ethanol precipitation and column chromatography. The results showed that CMPP-1 and CMPP-2 were hetero-galacturonans with different molecular weights of 7.35 kDa and 6.

Structural Analysis and Antioxidant Activity of Extracellular Polysaccharides Extracted from Culinary-Medicinal White Jelly Mushroom Tremella fuciformis (Tremellomycetes) Conidium Cells.

Using Tremella fuciformis conidium cells for submerged fermentation is a cost-effective way to harvest bioactive compounds. In this study, we emphasized the structural and functional analysis of extracellular polysaccharides (EPS) extracted from T. fuciformis conidium cells.

Adaptive Filtering Improved Apnea Detection Performance Using Tracheal Sounds in Noisy Environment: A Simulation Study.

Objective: Tracheal sounds were used to detect apnea on various occasions. However, ambient noises can contaminate tracheal sounds which result in poor performance of apnea detection. The objective of this paper was to apply the adaptive filtering (AF) algorithm to improve the quality of tracheal sounds and examine the accuracy of the apnea detection algorithm using tracheal sounds after AF.

Structural characterization and immune-enhancing activity of a novel high-molecular-weight polysaccharide from Cordyceps militaris.

A novel homogeneous polysaccharide (CMP-III) was extracted and purified from C. militaris. Structural characterization revealed that CMP-III had an average molecular weight of 4.

[Impacts of climate change on food production in Gansu: A review].

The climate of Gansu turned to be overall warming-drying and partly warming-wetting since 1986. In contrast to that of 1960, the average annual temperature had raised by 1.1°C with the average annual precipitation decreased by 28 mm correspondingly, which made the arid region expanded southward by 50 km in 2010.

Size control synthesis of polymer-stabilized water-soluble platinum oxide nanoparticles.

A series of narrowly distributed nanoparticles with different sizes of platinum oxide stabilized by polyvinylpyrrolidone (PVP) were synthesized by hydrolytic decomposition of platinum chloride. The as-synthesized nanoparticles were characterized by UV-vis, TEM, and XPS examination. Studies on the parameters influencing the size of the as-synthesized platinum oxide nanoparticles were carried out.

Synthesis of solvent-stabilized colloidal nanoparticles of platinum, rhodium, and ruthenium by microwave-polyol process.

Solvent-stabilized Pt, Rh, and Ru colloidal nanoparticles were synthesized by a microwave-polyol process. They were characterized by TEM and XPS, XRD, and UV-vis examination. These colloids have small particle sizes with narrow size distribution, and they were stable in glycol upon storage under ambient condition for months.

Unexpected effects of trace impurities on the properties of polymer-stabilized ruthenium colloids from different sources of ruthenium(III) chloride hydrate.

The stability and the catalytic performances of polyvinylpyrrolidone-stabilized ruthenium colloids (PVP-Ru) prepared by using RuCl(3).xH(2)O of different sources have been investigated. The trace impurity content of platinum and palladium in RuCl(3).