Silencing of CPNE1-TRAF2 Axis Restrains the Development of Pancreatic Cancer.

Background: Copine 1 (CPNE1) acts as a promoter in the progression of many kinds of cancers with the exception of pancreatic cancer (PC). This research is designed to probe the function of the CPNE1-tumor necrosis factor receptor-associated factor 2 (TRAF2) axis in PC.

Methods: and models of PC were constructed, and a series of biological function tests, including MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide], colony formation, flow cytometry, and immunohistochemistry, were performed.

High expression of Plnc RNA-1 promotes the progression of colorectal cancer.

Purpose: To study the expression of Plnc RNA-1 in colorectal cancer tissues and cells, and to explore the role of Plnc RNA-1 in the regulation of cell cycle and in the progression of colorectal cancer.

Methods: A total of 77 cases of colorectal cancer tissues were retrospectively analyzed. Thirty colorectal normal tissues composed the control group.